Nucleophiles directly substitute alcohols in the Mitsunobu reaction, but the process uses hazardous materials and generates an excessive amount of toxic waste. More than 50 years on from its initial discovery, chemists report a new catalytic version of the reaction, with water as the only by-product.

中文翻译：

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Mitsunobu改头换面

亲核试剂在Mitsunobu反应中直接替代醇，但是该过程使用危险材料，并产生大量有毒废物。自最初发现以来已有50多年的历史，化学家报告了该反应的新催化形式，其中水是唯一的副产物。