Duration of American football play and chronic traumatic encephalopathy,Annals of Neurology

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Duration of American football play and chronic traumatic encephalopathy
Annals of Neurology ( IF 8.1 ) Pub Date : 2019-11-23 , DOI: 10.1002/ana.25611
Jesse Mez _{1,

2,

3} , Daniel H Daneshvar _{1,

4} , Bobak Abdolmohammadi _{1,

2} , Alicia S Chua _{1,

5} , Michael L Alosco _{1,

2} , Patrick T Kiernan _{1,

2,

6} , Laney Evers _{1,

2} , Laura Marshall _{1,

2} , Brett M Martin _{1,

7} , Joseph N Palmisano _{1,

7} , Christopher J Nowinski _{1,

8} , Ian Mahar _{1,

2} , Jonathan D Cherry _{1,

9,

10} , Victor E Alvarez _{1,

9,

10} , Brigid Dwyer _{2,

11} , Bertrand R Huber _{1,

2,

9,

10} , Thor D Stein _{1,

3,

9,

10,

12} , Lee E Goldstein _{1,

2,

12,

13,

14} , Douglas I Katz _{2,

11} , Robert C Cantu _{1,

2,

8,

15,

16} , Rhoda Au _{1,

3,

17,

18} , Neil W Kowall _{1,

2,

9,

12} , Robert A Stern _{1,

2,

15,

17} , Michael D McClean ₁₉ , Jennifer Weuve ₁₈ , Yorghos Tripodis _{1,

5} , Ann C McKee _{1,

2,

3,

9,

10,

12}

Affiliation

Boston University Alzheimer's Disease and Chronic Traumatic Encephalopathy Center, Boston University School of Medicine, Boston, MA.
Department of Neurology, Boston University School of Medicine, Boston, MA.
Framingham Heart Study, Boston University School of Medicine, Boston, MA.
Department of Rehabilitation Medicine, Stanford University School of Medicine, Stanford, CA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA.
Midwestern University Arizona College of Osteopathic Medicine, Glendale, AZ.
Data Coordinating Center, Boston University School of Public Health, Boston, MA.
Concussion Legacy Foundation, Boston, MA.
VA Boston Healthcare System, US Department of Veteran Affairs, Boston, MA.
Department of Veterans Affairs Medical Center, Bedford, MA.
Braintree Rehabilitation Hospital, Braintree, MA.
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA.
Department of Psychiatry, Boston University School of Medicine, Boston, MA.
Department of Biomedical Engineering, Boston University College of Engineering, Boston, MA.
Department of Neurosurgery, Boston University School of Medicine, Boston, MA.
Department of Neurosurgery, Emerson Hospital, Concord, MA.
Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA.
Department of Epidemiology, Boston University School of Public Health, Boston, MA.
Department of Environmental Health, Boston University School of Public Health, Boston, MA.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to contact and collision sports, including American football. We hypothesized a dose–response relationship between duration of football played and CTE risk and severity.

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