C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease.,European Journal of Immunology

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C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2019-11-13 , DOI: 10.1002/eji.201847536
Kazuya Tone ₁ , Mark H T Stappers ₂ , Janet A Willment _{1,

2} , Gordon D Brown _{1,

2}

Affiliation

C-type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin-1 cluster, comprising of seven receptors including MICL, CLEC-2, CLEC-12B, CLEC-9A, MelLec, Dectin-1, and LOX-1. Reflecting the larger CLR family, the Dectin-1 cluster of receptors has a broad range of ligands and functions, but importantly, is involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis, and other autoimmune diseases. In this mini-review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin-1 cluster CLRs, focussing on their physiological roles and involvement in disease.

中文翻译：

Dectin-1 簇的 C 型凝集素受体：生理作用和参与疾病。

C 型凝集素受体 (CLR) 对多细胞存在至关重要，具有从胚胎发育到免疫功能的多种功能。CLR 的一个亚组是 Dectin-1 簇，由七种受体组成，包括 MICL、CLEC-2、CLEC-12B、CLEC-9A、MelLec、Dectin-1 和 LOX-1。反映更大的 CLR 家族，Dectin-1 受体簇具有广泛的配体和功能，但重要的是，它参与了许多调节健康和疾病的病理生理过程。事实上，这些受体与发育、感染、炎症调节、过敏、移植耐受、癌症、心血管疾病、关节炎和其他自身免疫疾病有关。在这篇小型评论中，我们讨论了阐明每个 Dectin-1 集群 CLR 的功能的最新进展，

更新日期：2019-11-13

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