A synthesis route to controlled and dynamic single polymer chain folding is reported. Sequence‐controlled macromolecules containing precisely located selenol moieties within a polymer chain are synthesized. Oxidation of selenol functionalities lead to diselenide bridges and induces controlled intramolecular crosslinking to generate single chain collapse. The cyclization process is successfully characterized by SEC as well as by ¹H NMR and 2D HSQC NMR spectroscopies. In order to gain insight on the molecular level to reveal the degree of structural control, the folded polymers are transformed into folded molecular brushes that are known to be visualizable as single molecule structures by AFM. The “grafting onto” approach is performed by using triazolinedione−diene reaction to graft the side chain polymers. A series of folded molecular brushes as well as the corresponding linear controls are synthesized. AFM visualization is proving the cyclization of the folded backbone by showing globular objects, where non‐folded brushes show typical worm‐like structures. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019

中文翻译：

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带有硒醇的分子瓶刷：通过原子力显微镜的构象分析扩展氧化单聚合物链折叠工具箱

报道了控制和动态单聚合物链折叠的合成途径。合成了在聚合物链中包含精确定位的硒醇部分的序列控制大分子。硒醇官能团的氧化导致二硒化物桥并诱导受控的分子内交联以产生单链塌陷。SEC和¹成功地表征了环化过程1 H NMR和2D HSQC NMR光谱学。为了深入了解分子水平以揭示结构控制的程度，将折叠后的聚合物转换成折叠后的分子刷，已知该笔刷可以通过AFM可视化为单分子结构。“接枝”方法是通过使用三唑啉二酮-二烯反应接枝侧链聚合物来进行的。合成了一系列折叠的分子刷以及相应的线性控件。AFM可视化通过显示球形物体证明了折叠骨架的环化，其中未折叠的刷子显示了典型的蠕虫状结构。分级为4 +©2019 Wiley Periodicals，Inc.J.Polym。科学，A部分：Polym。化学 2019年