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Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy.
Molecular Omics ( IF 3.0 ) Pub Date : 2019-12-02 , DOI: 10.1039/c9mo00117d Samuel Furse 1 , Sara L White , Claire L Meek , Benjamin Jenkins , Clive J Petry , Matias C Vieira , Susan E Ozanne , David B Dunger , Lucilla Poston , Albert Koulman
Molecular Omics ( IF 3.0 ) Pub Date : 2019-12-02 , DOI: 10.1039/c9mo00117d Samuel Furse 1 , Sara L White , Claire L Meek , Benjamin Jenkins , Clive J Petry , Matias C Vieira , Susan E Ozanne , David B Dunger , Lucilla Poston , Albert Koulman
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Gestational diabetes (GDM), a common pregnancy complication associated with obesity and long-term health risks, is usually diagnosed at approximately 28 weeks of gestation. An understanding of lipid metabolism in women at risk of GDM could contribute to earlier diagnosis and treatment. We tested the hypothesis that altered lipid metabolism at the beginning of the second trimester in obese pregnant women is associated with a diagnosis of GDM. Plasma samples from 831 participants (16-45 years, 15-18 weeks gestation, BMI ≥ 30) from the UPBEAT study of obese pregnant women were used. The lipid, sterol and glyceride fraction was isolated and analysed in a semi-quantitative fashion using direct infusion mass spectrometry. A combination of uni-, multi-variate and multi-variable statistical analyses was used to identify candidate biomarkers in plasma associated with a diagnosis of GDM (early third trimester; IADPSG criteria). Multivariable adjusted analyses showed that participants who later developed GDM had a greater abundance of several triglycerides (48:0, 50:1, 50:2, 51:5, 53:4) and phosphatidylcholine (38:5). In contrast sphingomyelins (32:1, 41:2, 42:3), lyso-phosphatidylcholine (16:0, 18:1), phosphatidylcholines (35:2, 40:7, 40:10), two polyunsaturated triglycerides (46:5, 48:6) and several oxidised triglycerides (48:6, 54:4, 56:4, 58:6) were less abundant. We concluded that both lipid and triglyceride metabolism were altered at least 10 weeks before diagnosis of GDM. Further investigation is required to determine the functional consequences of these differences and the mechanisms by which they arise.
中文翻译：
肥胖妊娠中甘油三酯和磷脂代谢的改变早于妊娠糖尿病的诊断。
妊娠糖尿病 (GDM) 是一种常见的妊娠并发症，与肥胖和长期健康风险相关，通常在妊娠 28 周左右被诊断出来。了解有 GDM 风险的女性的脂质代谢可能有助于早期诊断和治疗。我们检验了这样的假设：肥胖孕妇在妊娠中期初期脂质代谢的改变与 GDM 的诊断相关。使用来自肥胖孕妇 UPBEAT 研究的 831 名参与者（16-45 岁，妊娠 15-18 周，BMI ≥ 30）的血浆样本。使用直接输注质谱法以半定量方式分离和分析脂质、甾醇和甘油酯部分。采用单变量、多变量和多变量统计分析的组合来识别血浆中与 GDM 诊断相关的候选生物标志物（妊娠晚期；IADPSG 标准）。多变量调整分析显示，后来患上 GDM 的参与者的几种甘油三酯（48:0、50:1、50:2、51:5、53:4）和磷脂酰胆碱（38:5）含量更高。相比之下，鞘磷脂 (32:1、41:2、42:3)、溶血磷脂酰胆碱 (16:0、18:1)、磷脂酰胆碱 (35:2、40:7、40:10)、两种多不饱和甘油三酯 (46 :5、48:6）和几种氧化甘油三酯（48:6、54:4、56:4、58:6）的含量较低。我们得出的结论是，在诊断 GDM 之前至少 10 周，脂质和甘油三酯代谢均发生改变。需要进一步调查以确定这些差异的功能后果及其产生的机制。
更新日期：2019-12-02
中文翻译：
肥胖妊娠中甘油三酯和磷脂代谢的改变早于妊娠糖尿病的诊断。
妊娠糖尿病 (GDM) 是一种常见的妊娠并发症，与肥胖和长期健康风险相关，通常在妊娠 28 周左右被诊断出来。了解有 GDM 风险的女性的脂质代谢可能有助于早期诊断和治疗。我们检验了这样的假设：肥胖孕妇在妊娠中期初期脂质代谢的改变与 GDM 的诊断相关。使用来自肥胖孕妇 UPBEAT 研究的 831 名参与者（16-45 岁，妊娠 15-18 周，BMI ≥ 30）的血浆样本。使用直接输注质谱法以半定量方式分离和分析脂质、甾醇和甘油酯部分。采用单变量、多变量和多变量统计分析的组合来识别血浆中与 GDM 诊断相关的候选生物标志物（妊娠晚期；IADPSG 标准）。多变量调整分析显示，后来患上 GDM 的参与者的几种甘油三酯（48:0、50:1、50:2、51:5、53:4）和磷脂酰胆碱（38:5）含量更高。相比之下，鞘磷脂 (32:1、41:2、42:3)、溶血磷脂酰胆碱 (16:0、18:1)、磷脂酰胆碱 (35:2、40:7、40:10)、两种多不饱和甘油三酯 (46 :5、48:6）和几种氧化甘油三酯（48:6、54:4、56:4、58:6）的含量较低。我们得出的结论是，在诊断 GDM 之前至少 10 周，脂质和甘油三酯代谢均发生改变。需要进一步调查以确定这些差异的功能后果及其产生的机制。
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