The study evaluated whether it is psychomotor speed or higher-order cognitive processing which is primarily affected by antiepileptic drug (AED) treatment in epilepsy and whether computerized testing versus paper-pencil testing of executive functions is more sensitive. In this retrospective observational study, 55 patients with epilepsy underwent NeuroCog FXⓇ, a computerized battery assessing "psychomotor speed/alertness" and "cognitive processing" via 8 tasks, and EpiTrackⓇ, a paper-pencil screening of "executive functions and working memory" based on 6 subtests. Test performance was related to the number of drugs and the Defined Daily Dose and the presence/absence of AEDs with known adverse psychotropic effects. EpiTrackⓇ performance correlated with "cognitive processing" of the NeuroCog FXⓇ but not with "psychomotor speed/alertness". Significant correlations with drug load were mainly yielded for EpiTrackⓇ (number of AEDs: r = -0.551, total DDD: r = -0.452) and "cognitive processing" (number of AEDs: r = -0.433, total DDD: r = -0.415). "Psychomotor speed/alertness" was less related to drug load (number of AEDs: r = -0.285, total DDD: r = -0.232). Statistical control for "psychomotor speed/alertness" hardly changed the correlations of EpiTrackⓇ or "cognitive processing" with drug load indices. AEDs with known adverse profiles negatively affected EpiTrackⓇ and the "cognitive processing" but not the "psychomotor speed/alertness" domain of the computerized test. The results demonstrate that it is less basal psychomotor speed than higher-order cognitive processing which is negatively affected by antiepileptic pharmacotherapy. The results question the value of (computer-)tests with a major emphasis on psychomotor speed and alertness for cognitive drug monitoring.

中文翻译：

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心理运动速度的计算机化评估是否比专注于高阶认知处理的测试对抗癫痫药物疗法的认知影响更敏感？对选择敏感测试参数的影响

该研究评估了主要受癫痫抗癫痫药物 (AED) 治疗影响的是精神运动速度还是高级认知处理，以及计算机化测试与执行功能的纸笔测试是否更敏感。在这项回顾性观察性研究中，55 名癫痫患者接受了 NeuroCog FXⓇ（一种通过 8 项任务评估“精神运动速度/警觉性”和“认知处理”的计算机电池）和 EpiTrackⓇ（一种对“执行功能和工作记忆”的纸笔筛选） "基于 6 个子测试。测试性能与药物数量和确定的每日剂量以及具有已知不良精神作用的 AED 的存在/不存在有关。EpiTrackⓇ 性能与“认知处理”相关 NeuroCog FXⓇ 但不具有“精神运动速度/警觉性”。与载药量显着相关的主要是 EpiTrackⓇ（AED 数量：r = -0.551，总 DDD：r = -0.452）和“认知加工”（AED 数量：r = -0.433，总 DDD：r = - 0.415）。“精神运动速度/警觉性”与药物负荷的相关性较小（AED 数量：r = -0.285，总 DDD：r = -0.232）。“精神运动速度/警觉性”的统计控制几乎没有改变 EpiTrackⓇ 或“认知加工”与药物负荷指数的相关性。具有已知不良特征的 AED 会对 EpiTrackⓇ 和“认知处理”产生负面影响，但不会影响计算机测试的“精神运动速度/警觉性”领域。结果表明，与受到抗癫痫药物疗法负面影响的高阶认知处理相比，它的基础精神运动速度较低。结果质疑（计算机）测试的价值，主要强调认知药物监测的精神运动速度和警觉性。