B cells play multiple important roles in the pathophysiology of autoimmune disease. Beyond producing pathogenic autoantibodies, B cells can act as antigen-presenting cells and producers of cytokines, including both proinflammatory and anti-inflammatory cytokines. Here we review our current understanding of the non-antibody-secreting roles that B cells may play during development of autoimmunity, as learned primarily from reductionist preclinical models. Attention is also given to concepts emerging from clinical studies using B cell depletion therapy, which shed light on the roles of these mechanisms in human autoimmune disease.

中文翻译：

---

B 细胞的非抗体分泌功能及其对自身免疫性疾病的贡献。

B细胞在自身免疫性疾病的病理生理学中发挥多种重要作用。除了产生致病性自身抗体外，B 细胞还可以作为抗原呈递细胞和细胞因子的产生者，包括促炎和抗炎细胞因子。在这里，我们回顾了我们目前对 B 细胞在自身免疫发展过程中可能发挥的非抗体分泌作用的理解，这主要是从还原论的临床前模型中了解到的。还关注使用 B 细胞耗竭疗法的临床研究中出现的概念，这些概念阐明了这些机制在人类自身免疫性疾病中的作用。