Molecular cross talk between the nervous and vascular systems is necessary to maintain the correct coupling of organ structure and function. Molecular pathways shared by both systems are emerging as major players in the communication of the neuronal compartment with the endothelium. Here we review different aspects of this cross talk and how vessels influence the development and homeostasis of the nervous system. Beyond the classical role of the vasculature as a conduit to deliver oxygen and metabolites needed for the energy-demanding neuronal compartment, vessels emerge as powerful signaling systems that control and instruct a variety of cellular processes during the development of neurons and glia, such as migration, differentiation, and structural connectivity. Moreover, a broad spectrum of mild to severe vascular dysfunctions occur in various pathologies of the nervous system, suggesting that mild structural and functional changes at the neurovascular interface may underlie cognitive decline in many of these pathological conditions.

中文翻译：

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神经系统中的神经血管相互作用。

神经和血管系统之间的分子串扰对于维持器官结构和功能的正确耦合是必要的。这两个系统共享的分子途径正在成为神经元区室与内皮通讯的主要参与者。在这里，我们回顾了这种相声的不同方面，以及血管如何影响神经系统的发育和动态平衡。除了脉管系统作为输送氧气和能量代谢所需的代谢产物所需的氧气的管道的经典作用之外，血管还作为强大的信号系统出现，在神经元和神经胶质细胞的发育过程中控制和指导多种细胞过程，例如迁移，差异化和结构连通性。而且，