Forcing single-chain nanoparticle collapse through hydrophobic solvent interactions in comb copolymers†,Polymer Chemistry

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Forcing single-chain nanoparticle collapse through hydrophobic solvent interactions in comb copolymers†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2019-10-08 , DOI: 10.1039/c9py01235d
Cheyenne H. Liu _{1,

2,

3,

4} , Logan D. Dugas _{1,

2,

3,

4} , Jared I. Bowman _{1,

2,

3,

4} , Tamuka Chidanguro _{1,

2,

3,

4} , Robson F. Storey _{1,

2,

3,

4} , Yoan C. Simon _{1,

2,

3,

4}

Affiliation

We introduce a novel synthetic strategy in which high molecular weight comb copolymers with aliphatic side chains can collapse into single-chain nanoparticles (SNCPs) via photodimerization of anthracene under ultraviolet (UV) irradiation. By deliberately selecting hydrophobic comonomers with disparate solvency, we demonstrated that we could control chain collapse. We attribute these results to the formation of pseudo-unimicellar structures, whereby polyisobutylene (PIB) side chains are preferentially solvated, thereby compressing anthracene moieties to form a denser crosslinked core. The control of hydrophobic interactions is a common occurrence in proteins and we believe that our approach can be further extended to achieve multi-compartment SCNPs whereby each section is responsible for a given function.

中文翻译：

通过梳状共聚物中的疏水性溶剂相互作用迫使单链纳米颗粒塌陷†

我们介绍了一种新颖的合成策略，其中具有脂肪族侧链的高分子量梳状共聚物可以在紫外线（UV）照射下通过蒽的光二聚作用塌陷成单链纳米颗粒（SNCP）。通过有选择地选择具有不同溶解力的疏水性共聚单体，我们证明了我们可以控制链塌陷。我们将这些结果归因于伪单胶束结构的形成，其中聚异丁烯（PIB）侧链优先被溶剂化，从而压缩蒽部分以形成更致密的交联核心。疏水相互作用的控制是蛋白质中的常见现象，我们相信我们的方法可以进一步扩展以实现多室SCNP，其中每个部分负责给定的功能。

更新日期：2020-01-02

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