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Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK.
Nutrition & Diabetes ( IF 4.6 ) Pub Date : 2019-10-07 , DOI: 10.1038/s41387-019-0095-8
Sen Li 1 , Yan Zhang 2 , Yewu Sun 3 , Guangzhen Zhang 1 , Jie Bai 1 , Jianfei Guo 1 , Xudong Su 1 , Hongquan Du 1 , Xi Cao 4 , Jinkui Yang 4 , Ting Wang 5
Affiliation  

BACKGROUND Gestational diabetes mellitus (GDM) is a temporary form of diabetes during pregnancy, which influences the health of maternal-child in clinical practice. It is still urgent to develop new effective treatment for GDM. Naringenin is a bioactive ingredient with multiple activities including anti-diabetic. In current study, the effects of naringenin on GDM symptoms, insulin tolerance, inflammation, and productive outcomes were evaluated and the underlying mechanisms were explored. METHODS We administrated naringenin to GDM mice and monitored the GDM symptoms, glucose and insulin tolerance, inflammation and productive outcomes. We established tumor necrosis factor alpha (TNF-α)-induced insulin resistance skeletal muscle cell model and evaluated the effects of naringenin on reactive oxygen species (ROS) production, glucose uptake and glucose transporter type 4 (GLUT4) membrane translocation. RESULTS We found that naringenin ameliorated GDM symptoms, improved glucose and insulin tolerance, inhibited inflammation, and improved productive outcomes. It was further found that naringenin inhibited TNF-α-induced ROS production, enhanced GLUT4 membrane translocation, and glucose uptake, which were abolished by inhibition of AMP-activated protein kinase (AMPK). CONCLUSION Naringenin improves insulin sensitivity in gestational diabetes mellitus mice in an AMPK-dependent manner.

中文翻译:

柚皮苷通过AMPK改善妊娠糖尿病小鼠的胰岛素敏感性。

背景技术妊娠期糖尿病(GDM)是怀孕期间糖尿病的一种临时形式,其在临床实践中影响母婴的健康。迫切需要为GDM开发新的有效治疗方法。柚皮苷是一种具有多种活性的生物活性成分,包括抗糖尿病药。在当前的研究中,柚皮苷对GDM症状,胰岛素耐受性,炎症和生产性结果的影响进行了评估,并探讨了其潜在机制。方法我们将柚皮素给予GDM小鼠,并监测GDM症状,葡萄糖和胰岛素耐受性,炎症和生产成果。我们建立了肿瘤坏死因子α(TNF-α)诱导的胰岛素抵抗骨骼肌细胞模型,并评估了柚皮苷对活性氧(ROS)产生的影响,葡萄糖摄取和4型葡萄糖转运蛋白(GLUT4)膜移位。结果我们发现柚皮苷改善了GDM症状,改善了葡萄糖和胰岛素耐受性,抑制了炎症,并改善了生产成果。进一步发现,柚皮苷抑制TNF-α诱导的ROS产生,增强的GLUT4膜移位和葡萄糖摄取,这通过抑制AMP激活的蛋白激酶(AMPK)来消除。结论柚皮苷以依赖AMPK的方式提高妊娠糖尿病小鼠的胰岛素敏感性。通过抑制AMP激活的蛋白激酶(AMPK)消除了GLUT4膜易位和葡萄糖摄取的增强。结论柚皮苷以依赖AMPK的方式提高妊娠糖尿病小鼠的胰岛素敏感性。通过抑制AMP激活的蛋白激酶(AMPK)消除了GLUT4膜易位和葡萄糖摄取的增强。结论柚皮苷以依赖AMPK的方式提高妊娠糖尿病小鼠的胰岛素敏感性。
更新日期:2019-10-07
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