Google Trends (GT) is a free, easily accessible search tool which can be used to analyze worldwide “big data” on the relative popularity of search terms over a specific period of time. To determine worldwide public interest in Peyronie’ disease (PD), erectile dysfunction (ED), premature ejaculation (PE) treatments, their penetrance, variation, and how they compare over time. Worldwide search-engine trends analysis included electronic Google queries from people who searched PD, ED, and PE treatments options from January 2004 to October 2018, worldwide. Join-point regression (JPR) has been performed. Comparison annual relative search volume (ARSV), average annual percentage change (AAPC) and temporal patterns were analyzed to assess loss or gain of interest. Our results showed that for PD it has been a decreased interest for Drug (AAPC: −3.1%, p < 0.01), ESWT (AAPC: −3.1%, p < 0.01), and vacuum therapy (AAPC: −1.2%, p < 0.01). In the field of ED, we observed trends toward an increased interest in prosthetic surgical treatment (AAPC: +1.7%, p = 0.4), for prostaglandins (AAPC: +0.7%, p = 0.7), for traction (AAPC: +0.6%, p = 0.1) and for ESWT (AAPC: +1.8%, p = 0.4), but without statistical significance. On the contrary, we observed a slight reduction of search for Vacuum device (AAPC: −1 %, p < 0.01). The interest in PE decreased from 2004 to today (AAPC: −1%, p < 0.01), for surgical treatment (AAPC: −3.1%, p < 0.01), drug treatment (AAPC: −3.1%, p < 0.01), and for psychotherapy (AAPC: −6.7%, p < 0.01). On the contrary, the interest in spray drugs has increased significantly (AAPC: +5.1%, p < 0.01). Patients are searching the web for sexual diseases treatment options. Understanding people inquisitiveness together with degree of knowledge could be supportive to guide counseling in the decision-making-process and put effort in certifying patient information, avoiding them to fall in the pernicious trap of ‘fake-news’.

Google趋势（GT）是一个免费的，易于访问的搜索工具，可用于分析特定时期内搜索词相对受欢迎程度的全球“大数据”。为了确定全世界公众对Peyronie病（PD），勃起功能障碍（ED），早泄（PE）治疗，其渗透率，变异以及它们随时间的比较方式的关注。全球搜索引擎趋势分析包括2004年1月至2018年10月在全球范围内搜索PD，ED和PE治疗选项的人的Google电子查询。连接点回归（JPR）已执行。分析比较年度相对搜索量（ARSV），平均年度百分比变化（AAPC）和时间模式，以评估兴趣的损失或获得。我们的结果表明，对于PD，对药物的兴趣有所下降（AAPC：−3.1％，p  <0.01），ESWT（AAPC：-3.1％，p  <0.01）和真空疗法（AAPC：-1.2％，p  <0.01）。在ED领域，我们观察到对假体外科治疗（AAPC：+ 1.7％，p  = 0.4），对前列腺素（AAPC：+ 0.7％，p  = 0.7），对牵引（AAPC：+0.6）的兴趣增加的趋势。 ％，p  = 0.1）和ESWT（AAPC：+ 1.8％，p  = 0.4），但无统计学意义。相反，我们发现真空装置的搜索量略有下降（AAPC：-1％，p  <0.01）。从2004年至今，对PE的兴趣下降了（AAPC：-1％，p  <0.01），而手术治疗（AAPC：-3.1％，p <0.01），药物治疗（AAPC：-3.1％，p  <0.01）和心理治疗（AAPC：-6.7％，p  <0.01）。相反，对喷雾药物的兴趣显着增加（AAPC：+ 5.1％，p  <0.01）。病人正在网上寻找性疾病的治疗选择。了解人们的好奇心和知识程度可能有助于指导决策过程中的咨询，并努力对患者信息进行认证，避免他们陷入“假新闻”的危险陷阱。