Age is in the nucleus.,Nature Metabolism

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Age is in the nucleus.
Nature Metabolism ( IF 18.9 ) Pub Date : 2019-10-07 , DOI: 10.1038/s42255-019-0125-9
Björn Schumacher _{1,

2} , Jan Vijg _{3,

4}

Affiliation

Nuclear DNA damage has detrimental effects on cellular homoeostasis and accelerates the ageing process. A new study causally links error-prone mitochondrial replication to increased nuclear DNA damage, thus suggesting that the hallmarks of ageing are associated with nuclear genome instability, a potential unifying denominator in the ageing process.

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