Recent insights into natural product inhibitors of matrix metalloproteinases.,RSC Medicinal Chemistry

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Recent insights into natural product inhibitors of matrix metalloproteinases.
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2019-10-07 , DOI: 10.1039/c9md00165d
Geetha B Kumar ₁ , Bipin G Nair ₁ , J Jefferson P Perry _{1,

2} , David B C Martin _{3,

4}

Affiliation

Members of the matrix metalloproteinase (MMP) family have biological functions that are central to human health and disease, and MMP inhibitors have been investigated for the treatment of cardiovascular disease, cancer and neurodegenerative disorders. The outcomes of initial clinical trials with the first generation of MMP inhibitors proved disappointing. However, our growing understanding of the complexities of the MMP function in disease, and an increased understanding of MMP protein architecture and control of activity now provide new opportunities and avenues to develop MMP-focused therapies. Natural products that affect MMP activities have been of strong interest as templates for drug discovery, and for their use as chemical tools to help delineate the roles of MMPs that still remain to be defined. Herein, we highlight the most recent discoveries of structurally diverse natural product inhibitors to these proteases.

中文翻译：

对基质金属蛋白酶天然产物抑制剂的最新见解。

基质金属蛋白酶 (MMP) 家族的成员具有对人类健康和疾病至关重要的生物学功能，MMP 抑制剂已被研究用于治疗心血管疾病、癌症和神经退行性疾病。第一代 MMP 抑制剂的初步临床试验结果令人失望。然而，我们对疾病中 MMP 功能的复杂性的日益了解，以及对 MMP 蛋白结构和活性控制的更多了解，现在为开发以 MMP 为重点的疗法提供了新的机会和途径。影响 MMP 活性的天然产物作为药物发现的模板，以及作为化学工具来帮助描述仍有待定义的 MMP 的作用，引起了人们的浓厚兴趣。在此，我们重点介绍这些蛋白酶结构多样的天然产物抑制剂的最新发现。

更新日期：2019-12-13

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