Epstein-Barr Virus (EBV) is etiologically associated with multiple human malignancies including Burkitt lymphoma and Hodgkin disease as well as nasopharyngeal and gastric carcinoma. Entry of EBV into target cells is essential for virus to cause disease and is mediated by multiple viral envelope glycoproteins and cell surface associated receptors. The target cells of EBV include B cells and epithelial cells. The nature and mechanism of EBV entry into these cell types are different, requiring different glycoprotein complexes to bind to specific receptors on the target cells. Compared to the B cell entry mechanism, the overall mechanism of EBV entry into epithelial cells is less well known. Numerous receptors have been implicated in this process and may also be involved in additional processes of EBV entry, transport, and replication. This review summarizes EBV glycoproteins, host receptors, signal molecules and transport machinery that are being used in the epithelial cell entry process and also provides a broad view for related herpesvirus entry mechanisms.

中文翻译：

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爱泼斯坦-巴尔病毒感染上皮细胞。

爱泼斯坦-巴尔病毒（EBV）在病因上与多种人类恶性肿瘤有关，包括伯基特淋巴瘤和霍奇金病以及鼻咽癌和胃癌。EBV进入靶细胞对于病毒引起疾病至关重要，并由多种病毒包膜糖蛋白和细胞表面相关受体介导。EBV的靶细胞包括B细胞和上皮细胞。EBV进入这些细胞类型的性质和机制是不同的，需要不同的糖蛋白复合物与靶细胞上的特定受体结合。与B细胞进入机制相比，EBV进入上皮细胞的总体机制尚不为人所知。许多受体参与了该过程，也可能参与了EBV进入，运输和复制的其他过程。