It's widely appreciated that liquid-liquid phase separation (LLPS) underlies the formation of membraneless organelles, which function to concentrate proteins and nucleic acids. In the past few decades, major efforts have been devoted to identify the phase separation associated proteins and elucidate their functions. To better utilize the knowledge dispersed in published literature, we developed PhaSepDB (http://db.phasep.pro/), a manually curated database of phase separation associated proteins. Currently, PhaSepDB includes 2914 non-redundant proteins localized in different organelles curated from published literature and database. PhaSepDB provides protein summary, publication reference and sequence features of phase separation associated proteins. The sequence features which reflect the LLPS behavior are also available for other human protein candidates. The online database provides a convenient interface for the research community to easily browse, search and download phase separation associated proteins. As a centralized resource, we believe PhaSepDB will facilitate the future study of phase separation.

中文翻译：

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PhaSepDB：液相-液相分离相关蛋白的数据库。

众所周知，液-液相分离（LLPS）是无膜细胞器形成的基础，无细胞器的作用是浓缩蛋白质和核酸。在过去的几十年中，人们致力于识别相分离相关蛋白并阐明其功能。为了更好地利用已发表文献中散布的知识，我们开发了PhaSepDB（http://db.phasep.pro/），这是一种人工整理的相分离相关蛋白数据库。目前，PhaSepDB包含2914种非冗余蛋白，这些蛋白位于已发表的文献和数据库中确定的不同细胞器中。PhaSepDB提供蛋白质摘要，出版物参考以及相分离相关蛋白质的序列特征。反映LLPS行为的序列特征也可用于其他人蛋白质候选物。在线数据库为研究界提供了方便的界面，以方便地浏览，搜索和下载相分离相关蛋白。作为一个集中的资源，我们相信PhaSepDB将促进相分离的未来研究。