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The future of rodent models in depression research.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-10-02 , DOI: 10.1038/s41583-019-0221-6
Anand Gururajan 1, 2, 3 , Andreas Reif 4 , John F Cryan 5, 6 , David A Slattery 4
Affiliation  

Currently, over 300 million people worldwide have depression, and the socioeconomic burden of this debilitating disorder is anticipated to increase markedly over the coming decades against a background of increasing global turmoil. Despite this impending crisis, we are still waiting for improved therapeutic options for this disorder to emerge, which has led to increasing criticism of the role and value of preclinical models of depression. In this Review, we examine this landscape, focusing firstly on issues related to the terminology used in this context and the myriad of preclinical approaches to modelling and assaying aspects of depression in rodents. We discuss the importance of sex as a biological variable and the controversial idea of intergenerational and transgenerational transmission of depressive-like traits. We then examine the technical strategies available to dissect these models and review emerging evidence for putative druggable disease mechanisms. Finally, we propose a brief framework for future research that makes optimal use of these models and will, we hope, accelerate the discovery of improved antidepressants.

中文翻译:

啮齿动物模型在抑郁症研究中的未来。

目前,全世界有3亿人患有抑郁症,在全球动荡加剧的背景下,这种衰弱性疾病的社会经济负担预计将在未来几十年中显着增加。尽管存在这一迫在眉睫的危机,但我们仍在等待针对这种疾病出现的更好的治疗选择,这已导致越来越多的人对临床前抑郁症模型的作用和价值提出批评。在这篇综述中,我们研究了这种情况,首先关注与在此背景下使用的术语有关的问题以及用于对啮齿类动物的抑郁症进行建模和分析的大量临床前方法。我们讨论了性别作为一种生物学变量的重要性以及有关抑郁样特征的代际和跨代传播的争议性观点。然后,我们研究了可用于剖析这些模型的技术策略,并审查了可能的可药物性疾病机制的新证据。最后,我们为将来的研究提出了一个简短的框架,该框架可以最佳地利用这些模型,并希望将加速发现改良的抗抑郁药。
更新日期:2019-10-03
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