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Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics
Toxicology Research ( IF 2.2 ) Pub Date : 2019-10-02 , DOI: 10.1039/c9tx00147f Fatemeh Amereh 1, 2 , Akbar Eslami 1, 2 , Simin Fazelipour 3 , Mohammad Rafiee 1, 2 , Mohammad Ismail Zibaii 4 , Mohammad Babaei 5
Toxicology Research ( IF 2.2 ) Pub Date : 2019-10-02 , DOI: 10.1039/c9tx00147f Fatemeh Amereh 1, 2 , Akbar Eslami 1, 2 , Simin Fazelipour 3 , Mohammad Rafiee 1, 2 , Mohammad Ismail Zibaii 4 , Mohammad Babaei 5
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Toxicity evaluations of micro- or nano-sized plastics in rodent species commonly employed for toxicity analyses based on which risk assessment for humans could be performed are still largely lacking. Given this knowledge gap, the present work was aimed at determining the potential impact of chronic exposure to polystyrene nanoplastics (PS NPs) on the thyroid endocrine status and biochemical stress in a rat model. Young adult male rats were orally administered with PS NPs (1, 3, 6 and 10 mg kg−1 day−1) for five weeks. Thyroid hormones (THs) L-thyroxine (T4), L-triiodothyronine (T3), L-free triiodothyronine (FT3), and L-free thyroxine (FT4) as well as thyroid stimulating hormone (TSH) serum levels of normal rats and those exposed to PS NPs were compared. Serum levels of high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, and creatinine, as well as glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) enzymes were also measured. Exposure to PS NPs suppressed the serum levels of T3 and circulating levels of THs, whereas TSH increased significantly. Though exposure to PS NPs did not affect the molar ratios of T3/T4, it induced a slight, but significant, increase in FT3/FT4. In addition, exposure to plastic nanoparticles showed signs of nephrotoxicity induction and kidney injury in exposed organisms as can be inferred from the significantly higher serum levels of creatinine in exposed groups. Our results provide clear evidence of an association between exposure to plastic NPs and thyroid endocrine disruption as well as metabolic deficit, and generate new leads for future research efforts.
中文翻译：
长期暴露于原始聚苯乙烯纳米塑料的成年雄性Wistar大鼠的甲状腺内分泌状态和生化应激反应
仍然普遍缺乏对通常用于毒性分析的啮齿类动物中的微米级或纳米级塑料进行毒性评估的依据。鉴于这种知识差距，本研究旨在确定长期暴露于聚苯乙烯纳米塑料（PS NPs）对大鼠模型中甲状腺内分泌状态和生化应激的潜在影响。给成年雄性大鼠口服PS NP（1、3、6和10 mg kg -1天-1），持续5周。甲状腺激素（THs）L-甲状腺素（T4），L-三碘甲状腺素（T3），无L三碘甲状腺素（FT3）和L比较正常大鼠和暴露于PS NPs的无甲状腺素（FT4）以及甲状腺刺激激素（TSH）血清水平。还测量了血清高密度脂蛋白（HDL），低密度脂蛋白（LDL），胆固醇和肌酐的水平，以及谷氨酸草酰乙酸转氨酶（GOT）和谷氨酸丙酮酸转氨酶（GPT）的酶。暴露于PS NPs可抑制T3的血清水平和THs的循环水平，而TSH则显着增加。尽管暴露于PS NPs不会影响T3 / T4的摩尔比，但会引起FT3 / FT4的轻微但显着的增加。此外，暴露于塑料纳米颗粒在暴露的生物体中显示出肾毒性诱导和肾脏损伤的迹象，这可以从暴露组中肌酐的血清水平明显升高来推断。
更新日期：2019-10-02
中文翻译：
长期暴露于原始聚苯乙烯纳米塑料的成年雄性Wistar大鼠的甲状腺内分泌状态和生化应激反应
仍然普遍缺乏对通常用于毒性分析的啮齿类动物中的微米级或纳米级塑料进行毒性评估的依据。鉴于这种知识差距，本研究旨在确定长期暴露于聚苯乙烯纳米塑料（PS NPs）对大鼠模型中甲状腺内分泌状态和生化应激的潜在影响。给成年雄性大鼠口服PS NP（1、3、6和10 mg kg -1天-1），持续5周。甲状腺激素（THs）L-甲状腺素（T4），L-三碘甲状腺素（T3），无L三碘甲状腺素（FT3）和L比较正常大鼠和暴露于PS NPs的无甲状腺素（FT4）以及甲状腺刺激激素（TSH）血清水平。还测量了血清高密度脂蛋白（HDL），低密度脂蛋白（LDL），胆固醇和肌酐的水平，以及谷氨酸草酰乙酸转氨酶（GOT）和谷氨酸丙酮酸转氨酶（GPT）的酶。暴露于PS NPs可抑制T3的血清水平和THs的循环水平，而TSH则显着增加。尽管暴露于PS NPs不会影响T3 / T4的摩尔比，但会引起FT3 / FT4的轻微但显着的增加。此外，暴露于塑料纳米颗粒在暴露的生物体中显示出肾毒性诱导和肾脏损伤的迹象，这可以从暴露组中肌酐的血清水平明显升高来推断。
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