Synthetic ecology of the human gut microbiota.,Nature Reviews Microbiology

当前位置： X-MOL 学术 › Nat. Rev. Microbiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthetic ecology of the human gut microbiota.
Nature Reviews Microbiology ( IF 69.2 ) Pub Date : 2019-10-02 , DOI: 10.1038/s41579-019-0264-8
Gino Vrancken _{1,

2} , Ann C Gregory _{1,

2} , Geert R B Huys _{1,

2} , Karoline Faust ₁ , Jeroen Raes _{1,

2}

Affiliation

Despite recent advances in sequencing and culturing, a deep knowledge of the wiring and functioning of the human gut ecosystem and its microbiota as a community is still missing. A holistic mechanistic understanding will require study of the gut microbiota as an interactive and spatially organized biological system, which is difficult to do in complex natural communities. Synthetic gut microbial ecosystems can function as model systems to further current understanding of the composition, stability and functional activities of the microbiota. In this Review, we provide an overview of the current synthetic ecology strategies that can be used towards a more comprehensive understanding of the human gut ecosystem. Such approaches that integrate in vitro experiments using cultured isolates with mathematical modelling will enable the ultimate goal: translating mechanistic and ecological knowledge into novel and effective therapies.

中文翻译：

人体肠道微生物群的合成生态学。

尽管最近在测序和培养方面取得了进展，但仍然缺乏对人类肠道生态系统及其作为一个社区的微生物群的布线和功能的深入了解。全面的机制理解将需要研究肠道微生物群作为一个互动和空间组织的生物系统，这在复杂的自然群落中很难做到。合成肠道微生物生态系统可以作为模型系统，进一步了解当前对微生物群的组成、稳定性和功能活动的理解。在这篇综述中，我们概述了当前的合成生态学策略，这些策略可用于更全面地了解人类肠道生态系统。这种将使用培养分离物的体外实验与数学模型相结合的方法将实现最终目标：

更新日期：2019-10-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11