Deterioration of sexual function is associated with central hemodynamics in adult Japanese men,Hypertension Research

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Deterioration of sexual function is associated with central hemodynamics in adult Japanese men
Hypertension Research ( IF 4.3 ) Pub Date : 2019-10-01 , DOI: 10.1038/s41440-019-0336-1
Hiroshi Kumagai _{1,

2,

3} , Toru Yoshikawa _{1,

4} , Keisei Kosaki _{1,

3} , Kanae Myoenzono ₅ , Seiji Maeda ₁

Affiliation

Elevated aortic blood pressure is more strongly related to the onset of cardiovascular disease (CVD) than elevated brachial blood pressure. On the other hand, erectile dysfunction (ED) is a peripheral vascular disfunction and is also associated with CVD; however, the association between aortic blood pressure and ED has not yet been clarified. Therefore, we aimed to investigate the association between ED severity and aortic blood pressure in adult men. In 253 Japanese adult men (59 ± 16 years), aortic (estimated using a generalized transfer function) and peripheral hemodynamics were measured. Erectile function was assessed with a questionnaire (the International Index of Erectile Function 5: IIEF5), and participants were stratified into three groups based on the IIEF5 score (no ED, mild-to-moderate ED, and moderate-to-severe ED). Aortic systolic blood pressure (SBP) and pulse pressure (PP) were significantly higher in subjects with moderate-to-severe ED than in subjects with no ED or mild-to-moderate ED. In addition, the severity of ED was significantly associated with the time to reflection, augmentation pressure, and augmentation index. Multivariate linear regression analyses suggested that moderate-to-severe ED was significantly associated with aortic SBP and PP ( β = 0.129; p = 0.047, β = 0.165; p = 0.013, respectively) but not brachial SBP or PP, after confounding factors were considered. These results suggest that moderate-to-severe ED is associated with elevated aortic blood pressure due to an earlier arrival of the reflected wave and is an independent predictor of elevated aortic blood pressure in Japanese men.

中文翻译：

日本成年男性的性功能恶化与中枢血流动力学有关

与肱动脉血压升高相比，主动脉血压升高与心血管疾病 (CVD) 的发生更密切相关。另一方面，勃起功能障碍 (ED) 是一种外周血管功能障碍，也与心血管疾病有关。然而，主动脉血压与 ED 之间的关系尚未阐明。因此，我们旨在调查成年男性 ED 严重程度与主动脉血压之间的关联。在 253 名日本成年男性（59 ± 16 岁）中，测量了主动脉（使用广义传递函数估计）和外周血流动力学。使用问卷（国际勃起功能指数 5：IIEF5）评估勃起功能，并根据 IIEF5 评分将参与者分为三组（无 ED、轻度至中度 ED 和中度至重度 ED） . 中度至重度 ED 受试者的主动脉收缩压 (SBP) 和脉压 (PP) 显着高于没有 ED 或轻度至中度 ED 的受试者。此外，ED的严重程度与反射时间、增强压力和增强指数显着相关。多元线性回归分析表明，中度至重度 ED 与主动脉 SBP 和 PP 显着相关（分别为 β = 0.129；p = 0.047，β = 0.165；p = 0.013），但与肱动脉 SBP 或 PP 无关，在混杂因素被排除后经过考虑的。这些结果表明，由于反射波提前到达，中度至重度 ED 与主动脉血压升高有关，并且是日本男性主动脉血压升高的独立预测因素。

更新日期：2019-10-01

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