OBJECTIVE To elucidate the effects of meteorological variations on the activity of influenza A and B in 11 sites across different climate regions. METHODS Daily numbers of laboratory-confirmed influenza A and B cases from 2011-2015 were collected from study sites where the corresponding daily mean temperature, relative humidity, wind speed and daily precipitation amount were used for boosted regression trees analysis on the marginal associations and the interaction effects. RESULTS Cold temperature was a major determinant that favored both influenza A and B in temperate and subtropical sites. Temperature-to-influenza A, but not influenza B, exhibited a U-shape association in subtropical and tropical sites. High relative humidity was also associated with influenza activities but was less consistent with influenza B activity. Compared with relative humidity, absolute humidity had a stronger association - it was negatively associated with influenza B activity in temperate zones, but was positively associated with both influenza A and B in subtropical and tropical zones. CONCLUSION The association between meteorological factors and with influenza activity is virus type specific and climate dependent. The heavy influence of temperature on influenza activity across climate zones implies that global warming is likely to have an impact on the influenza burden.

中文翻译：

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气象变化与不同气候区的甲型和乙型流感活动之间的关联：全球范围内的多区域建模分析。

目的阐明气象变化对不同气候区域11个地点中甲型和乙型流感活性的影响。方法从研究地点收集2011-2015年实验室确诊的甲型和乙型流感病例的日数，并使用相应的日平均温度，相对湿度，风速和日降水量对边际关联性和相关性进行增强回归树分析。相互作用的影响。结果寒冷温度是温带和亚热带地区偏爱甲型和乙型流感的主要决定因素。在亚热带和热带地区，由温度引起的甲型流感病毒（而非乙型流感病毒）呈现U型关联。较高的相对湿度也与流感活动有关，但与乙型流感活动不太一致。与相对湿度相比，绝对湿度具有更强的关联性-在温带地区与乙型流感活动呈负相关，而在亚热带和热带地区与甲型和乙型流感均呈正相关。结论气象因素与流感活动之间的关联是特定病毒类型和气候依赖性的。温度对整个气候区流感活动的严重影响意味着全球变暖可能会对流感负担产生影响。结论气象因素与流感活动之间的关联是特定病毒类型和气候依赖性的。温度对整个气候区流感活动的严重影响意味着全球变暖可能会对流感负担产生影响。结论气象因素与流感活动之间的关联是病毒类型特异性和气候依赖性。温度对整个气候区流感活动的严重影响意味着全球变暖可能会对流感负担产生影响。