Premature Ejaculation (PE) is a very common and disturbing sexual dysfunction in men. Currently available treatment modalities are associated with limited efficacy and low treatment adherence. In this prospective, single-blinded, self-controlled study, we evaluated the efficacy and safety of transcutaneous electrical stimulation (TES) for the treatment of (PE). We included 23 patients aged 20–60 (mean: 38.7) with lifelong PE. On the first visit, we delivered either TES or sham treatment to the perineum, based on the enrollment order. For stimulation, we used a commercial neuromuscular electrical stimulation device. The patients were invited for the second visit after at least 7 days for receiving the alternating treatment. During the treatment sessions, the patients were left alone in a privet silent room to masturbate and a stopwatch was used to measure their masturbation ejaculatory latency time (MELT). The patients also filled-out safety questionnaires after each visit and on each of the 3 following days. Of the 20 patients who completed the study, 17 (85%) experienced prolonged MELT under TES compared with the sham treatment. Mean MELT values increased 3.5-folds under TES (p = 0.0009). We demonstrated a significant increase in MELT in lifelong PE patients using TES. This therapeutic option may have the potential to become an on-demand treatment option for PE. Future studies with wireless devices are needed to confirm the efficacy and safety of this treatment concept during intercourse.

早泄（PE）是男性中非常常见且令人不安的性功能障碍。当前可用的治疗方式与有限的疗效和低的治疗依从性相关。在这项前瞻性，单盲，自我对照研究中，我们评估了经皮电刺激（TES）治疗（PE）的功效和安全性。我们纳入了23名20至60岁（平均38.7岁）的终身性PE患者。第一次就诊时，我们根据入组顺序向会阴部提供了TES或假治疗。对于刺激，我们使用了商用神经肌肉电刺激设备。在至少7天后邀请患者进行第二次就诊，以接受交替治疗。在治疗期间，这些患者被留在一个女贞静静的房间里进行手淫，并使用秒表测量他们的手淫射精潜伏时间（MELT）。每次访视后以及接下来的3天中，患者还填写了安全调查表。与假手术相比，在完成研究的20位患者中，有17位（85％）在TES下经历了延长的MELT。在TES下，平均MELT值增加了3.5倍（p  = 0.0009）。我们证明了使用TES在终生PE患者中MELT显着增加。这种治疗选择可能有可能成为PE的按需治疗选择。需要对无线设备进行进一步的研究，以确认性交过程中该治疗方案的有效性和安全性。