Insulin resistance is associated with increased lipolysis and elevated concentrations of free fatty acids (FFA), which in turn contribute to impaired vascular function. It was hypothesized that lowering FFA with acipimox, a nicotinic acid derivative that impairs FFA efflux, would improve endothelial function, measured by flow‐mediated dilation (FMD), in individuals with metabolic syndrome.

中文翻译：

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Acipimox治疗对代谢综合征中游离脂肪酸流出和内皮功能的影响：一项随机试验。

胰岛素抵抗与脂肪分解增加和游离脂肪酸（FFA）浓度升高有关，这反过来又导致血管功能受损。据推测，用阿西莫克斯（一种降低了FFA外排的烟酸衍生物）降低FFA，可以改善代谢综合征患者的血管内皮功能（通过流介导的扩张（FMD）来衡量）。