Deformed wing virus (DWV) has become the most well-known, widespread, and intensively studied insect pathogen in the world. Although DWV was previously present in honeybee populations, the arrival and global spread of a new vector, the ectoparasitic mite Varroa destructor, has dramatically altered DWV epidemiology. DWV is now the most prevalent virus in honeybees, with a minimum average of 55% of colonies/apiaries infected across 32 countries. Additionally, DWV has been detected in 65 arthropod species spanning eight insect orders and three orders of Arachnida. Here, we describe the significant progress that has been made in elucidating the capsid structure of the virus, understanding its ever-expanding host range, and tracking the constantly evolving DWV genome and formation of recombinants. The construction of molecular clones, working with DWV in cell lines, and the development of immunohistochemistry methods will all help the community to move forward. Identifying the tissues in which DWV variants are replicating and understanding the impact of DWV in non-honeybee hosts are major new goals.

中文翻译：

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蜜蜂和其他昆虫中的变形翼病毒。

变形翅膀病毒（DWV）已成为世界上最著名，最广泛和深入研究的昆虫病原体。尽管以前在蜜蜂种群中存在DWV，但一种新的媒介（寄生螨螨Varroa破坏物）的到来和在全球范围的传播已大大改变了DWV的流行病学。DWV现在是蜜蜂中最流行的病毒，在32个国家/地区中，至少有55％的殖民地/养蜂场被感染。此外，已在65个节肢动物物种中检测到DWV，这些物种横跨8个昆虫纲和3个蜘蛛纲。在这里，我们描述了阐明病毒衣壳结构，了解其不断扩大的宿主范围以及跟踪不断发展的DWV基因组和重组体形成方面的重大进展。分子克隆的构建，与DWV在细胞系中的合作，以及免疫组织化学方法的发展都将帮助社区向前发展。识别DWV变异体正在复制的组织并了解DWV在非蜜蜂宿主中的影响是主要的新目标。