Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence has revealed that FoxO (forkhead box class O) transcription factors have a multifaceted role in autophagy regulation and dysregulation. Nuclear FoxOs transactivate genes that control the formation of autophagosomes and their fusion with lysosomes. Independently of transactivation, cytosolic FoxO proteins induce autophagy by directly interacting with autophagy proteins. Autophagy is also controlled by FoxOs through epigenetic mechanisms. Moreover, FoxO proteins can be degraded directly or indirectly by autophagy. Cutting-edge evidence is reviewed that the FoxO-autophagy axis plays a crucial role in health and disease.

中文翻译：

---

健康和疾病中的 FoxO-自噬轴

自噬控制细胞重塑和质量控制。失调的自噬与多种人类疾病有关，包括肥胖、糖尿病、心血管疾病、神经退行性疾病和癌症。目前的证据表明 FoxO（叉头盒 O 类）转录因子在自噬调节和失调中具有多方面的作用。核 FoxOs 激活控制自噬体形成及其与溶酶体融合的基因。独立于反式激活，胞质 FoxO 蛋白通过直接与自噬蛋白相互作用来诱导自噬。自噬也由 FoxOs 通过表观遗传机制控制。此外，FoxO 蛋白可以通过自噬直接或间接降解。