BACKGROUND Seafood consumption and dietary intake of n-3 polyunsaturated fatty acids (PUFA) protect from cardiovascular disease, muscle wasting and mortality; however, their role in delaying unhealthy ageing is uncertain. METHODS A prospective cohort study with 1592 community-dwelling individuals aged ≥60 years recruited in 2008-2010, and followed through 2015. Intake of seafood and n-3 PUFA [eicosapentanoic acid (EPA) and docosahexanoic acid (DHA)] was estimated using a validated diet history and food composition tables. Unhealthy ageing was assessed across the domains of physical and cognitive function, mental health, morbidity, self-rated health and vitality. RESULTS Higher blue fish consumption was negatively associated with unhealthy ageing in 2015 [multivariate ß (95% confidence interval) per interquartile range (IQR) increase of fish: -0.49 (-0.90; -0.08)] and, specifically, was associated with lower accumulation of functional impairments [-1.00 (-1.71; -0.28)] and morbidities [-0.30 (-0.73; 0.13)]. Individuals with high intakes of EPA (≥0.47 g/day) and DHA (≥0.89 g/day) presented the highest reductions in age-related deficits accumulation: -1.61 (-3.01; -0.22) and -1.34 (-2.76; 0.08), respectively. Intake of EPA and DHA were negatively associated with the accumulation of functional deficits [results per IQR increase: -0.79 (-1.64; -0.06) and -0.84 (-1.67; -0.01), respectively] and morbidities [-0.60 (-1.10; -1.11) and -0.60 (-1.09; -0.11)]. No associations were observed between n-3 PUFA and self-rated or mental health, or between white fish and unhealthy ageing. CONCLUSIONS In this cohort of Spanish individuals with elevated intake of fish and a high adherence to the Mediterranean diet, consumption of blue fish and n-3 PUFA had a prospective protective association with deficits accumulation.

中文翻译：

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膳食n-3多不饱和脂肪酸，鱼的摄入量和健康的衰老。

背景技术海鲜消费和饮食中摄入的n-3多不饱和脂肪酸（PUFA）可以预防心血管疾病，肌肉萎缩和死亡。但是，它们在延缓不健康衰老中的作用尚不确定。方法采用前瞻性队列研究方法，在2008年至2010年以及2015年之前对1592名年龄≥60岁的社区居民进行了研究，并采用以下方法估算了海鲜和n-3 PUFA [二十碳五酸（EPA）和二十二碳六烯酸（DHA）]的摄入量。经过验证的饮食史和食物成分表。在身体和认知功能，心理健康，发病率，自我评估的健康和活力等各个领域对不健康的衰老进行了评估。结果2015年，蓝色鱼的高消费与不健康的衰老呈负相关[鱼的四分位间距（IQR）增长的多变量ß（95％置信区间）：-0。49（-0.90; -0.08）]，特别是与功能障碍[-1.00（-1.71; -0.28）]和发病率[-0.30（-0.73; 0.13）]的较低积累相关。EPA（≥0.47g /天）和DHA（≥0.89g /天）摄入量高的人，与年龄相关的赤字累积减少量最大：-1.61（-3.01; -0.22）和-1.34（-2.76; 0.08） ）， 分别。EPA和DHA的摄入与功能障碍的累积呈负相关[每IQR增加的结果分别为-0.79（-1.64; -0.06）和-0.84（-1.67; -0.01）]和发病率[-0.60（-1.10） ； -1.11）和-0.60（-1.09; -0.11）]。在n-3 PUFA与自我评估或精神健康之间，或在白鱼与不健康的衰老之间未发现任何关联。