Autism spectrum disorder (ASD) is an increasingly common neurodevelopmental disorder that affects 1 in 59 children. The cognitive profiles of individuals with ASD are varied, and the neurophysiological underpinnings of these developmental difficulties are unclear. While many studies have focused on overall group differences in the amplitude or latency of event related potential (ERP) responses, recent research suggests that increased intra‐subject neural variability may also be a reliable indicator of atypical brain function in ASD. This study aimed to identify behavioral and neural variability responses during an emotional inhibitory control task in children with ASD compared to typically developing (TD) children. Children with ASD showed increased variability in response to both inhibitory and emotional stimuli, evidenced by greater reaction time variability and single‐trial ERP variability of N200 and N170 amplitudes and/or latencies compared to TD children. These results suggest that the physiological basis of ASD may be more accurately explained by increased intra‐subject variability, in addition to characteristic increases or decreases in the amplitude or latency of neural responses. Autism Res 2020, 13:221–229. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.

中文翻译：

---

自闭症谱系障碍儿童的反应时间和单项试验相关事件的潜在成分的受试者体内变异性增加。

自闭症谱系障碍（ASD）是一种日益普遍的神经发育障碍，影响59名儿童中的1名。患有ASD的个体的认知特征各不相同，这些发育困难的神经生理基础尚不清楚。尽管许多研究集中在事件相关电位（ERP）反应的幅度或潜伏期的整体群体差异上，但最近的研究表明，受试者内部神经变异性的增加也可能是ASD中非典型脑功能的可靠指标。这项研究旨在确定与典型发展中（TD）儿童相比，ASD儿童在情感抑制控制任务中的行为和神经变异反应。自闭症儿童表现出对抑制性和情绪刺激的反应性增加，与TD儿童相比，N200和N170振幅和/或潜伏期的反应时间变异性和单次ERP变异性更大。这些结果表明，除了特征性增加或减少神经反应的幅度或潜伏期外，受试者内部变异性的增加可以更准确地解释ASD的生理基础。Autism Res 2020，13：221–229。©2019国际自闭症研究会，Wiley Periodicals，Inc.