High-throughput sequencing of the adaptive immune receptor repertoire (AIRR-seq) is providing unprecedented insights into the immune response to disease and into the development of immune disorders. The accurate interpretation of AIRR-seq data depends on the existence of comprehensive germline gene reference sets. Current sets are known to be incomplete and unrepresentative of the degree of polymorphism and diversity in human and animal populations. A key issue is the complexity of the genomic regions in which they lie, which, because of the presence of multiple repeats, insertions and deletions, have not proved tractable with short-read whole genome sequencing. Recently, tools and methods for inferring such gene sequences from AIRR-seq datasets have become available, and a community approach has been developed for the expert review and publication of such inferences. Here, we present OGRDB, the Open Germline Receptor Database (https://ogrdb.airr-community.org), a public resource for the submission, review and publication of previously unknown receptor germline sequences together with supporting evidence.

中文翻译：

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OGRDB：推断的免疫受体基因的参考数据库。

自适应免疫受体库（AIRR-seq）的高通量测序为人们对疾病的免疫反应和免疫疾病的发展提供了空前的见识。对AIRR-seq数据的准确解释取决于综合种系基因参考集的存在。已知当前的集合不完整，不能代表人类和动物种群中的多态性和多样性。一个关键问题是它们所位于的基因组区域的复杂性，由于存在多个重复，插入和缺失，因此尚未证明在短读全基因组测序中很难处理。最近，从AIRR-seq数据集推断出此类基因序列的工具和方法已经变得可用，并且已经开发了一种社区方法，用于专家审查和发布此类推论。在这里，我们介绍OGRDB，开放生殖系受体数据库（https://ogrdb.airr-community.org），该公共资源可用于提交，审查和出版以前未知的受体种系序列以及支持性证据。