当前位置：
X-MOL 学术
›
Hypertens. Res.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Three-year change in oxidative stress markers is linked to target organ damage in black and white men: the SABPA study
Hypertension Research ( IF 4.3 ) Pub Date : 2019-09-30 , DOI: 10.1038/s41440-019-0325-4 Caitlynd Myburgh 1, 2 , Hugo W Huisman 1, 3 , Catharina M C Mels 1, 3
Hypertension Research ( IF 4.3 ) Pub Date : 2019-09-30 , DOI: 10.1038/s41440-019-0325-4 Caitlynd Myburgh 1, 2 , Hugo W Huisman 1, 3 , Catharina M C Mels 1, 3
Affiliation
|
Oxidative stress is implicated in hypertension, carotid wall thickening, and renal dysfunction. Oxidative stress is linked to cardiovascular pathology in the black South African individuals who have a high prevalence of hypertension and early vascular aging. However, there are limited data relating changes in oxidative stress with vascular and renal deterioration over time. We aimed to investigate whether changes in oxidative stress over 3 years are associated with target organ damage in black (N = 89) and white (N = 91) men. Carotid intima-media thickness was measured using the SonoSite Micromaxx ultrasound system, and cross-sectional wall area (CSWA) was calculated. The estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease formula. The percentage change (%∆) in oxidative stress markers was calculated and included reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR). Over 3 years, black men exhibited decreased ROS, SOD, and GR, while white men revealed decreased SOD and GPx. Black men displayed positive associations of CSWA with %∆ ROS (β = 0.28; p = 0.017) and %∆ SOD (β = 0.24; p = 0.047). White men displayed a negative association of CSWA with %∆ SOD (β = −0.22; p = 0.042) and positive associations of eGFR with %∆ GPx (β = 0.33; p = 0.001) and %∆ GR (β = 0.39; p < 0.001). In white men, the association of CSWA with decreased SOD activity suggests oxidative-stress-related carotid remodeling, while associations of eGFR with the glutathione system suggests a postponement of microvascular deterioration. In black men, associations of oxidative stress markers with CSWA suggest that a sufficiently functioning antioxidant system may delay target organ damage.
中文翻译：
氧化应激标志物的三年变化与黑人和白人男性的靶器官损伤有关：SABPA 研究
氧化应激与高血压、颈动脉壁增厚和肾功能障碍有关。氧化应激与高血压和早期血管老化高发的南非黑人个体的心血管病理学有关。然而，随着时间的推移，将氧化应激的变化与血管和肾脏的恶化相关联的数据有限。我们旨在调查 3 年内氧化应激的变化是否与黑人 (N = 89) 和白人 (N = 91) 男性的靶器官损伤有关。使用 SonoSite Micromaxx 超声系统测量颈动脉内膜中层厚度，并计算横截壁面积 (CSWA)。估计的肾小球滤过率 (eGFR) 使用肾病饮食修正公式计算。计算了氧化应激标志物的百分比变化 (%∆)，包括活性氧 (ROS)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GPx) 和谷胱甘肽还原酶 (GR)。3 年多来，黑人男性的 ROS、SOD 和 GR 下降，而白人男性的 SOD 和 GPx 下降。黑人显示 CSWA 与 %∆ ROS (β = 0.28; p = 0.017) 和 %∆ SOD (β = 0.24; p = 0.047) 呈正相关。白人显示 CSWA 与 %∆ SOD (β = -0.22; p = 0.042) 呈负相关，eGFR 与 %∆ GPx (β = 0.33; p = 0.001) 和 %∆ GR (β = 0.39; p) 呈正相关< 0.001)。在白人男性中，CSWA 与 SOD 活性降低的关联表明氧化应激相关的颈动脉重塑，而 eGFR 与谷胱甘肽系统的关联表明微血管恶化的延迟。
更新日期：2019-09-30
中文翻译：
氧化应激标志物的三年变化与黑人和白人男性的靶器官损伤有关：SABPA 研究
氧化应激与高血压、颈动脉壁增厚和肾功能障碍有关。氧化应激与高血压和早期血管老化高发的南非黑人个体的心血管病理学有关。然而，随着时间的推移，将氧化应激的变化与血管和肾脏的恶化相关联的数据有限。我们旨在调查 3 年内氧化应激的变化是否与黑人 (N = 89) 和白人 (N = 91) 男性的靶器官损伤有关。使用 SonoSite Micromaxx 超声系统测量颈动脉内膜中层厚度，并计算横截壁面积 (CSWA)。估计的肾小球滤过率 (eGFR) 使用肾病饮食修正公式计算。计算了氧化应激标志物的百分比变化 (%∆)，包括活性氧 (ROS)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GPx) 和谷胱甘肽还原酶 (GR)。3 年多来，黑人男性的 ROS、SOD 和 GR 下降，而白人男性的 SOD 和 GPx 下降。黑人显示 CSWA 与 %∆ ROS (β = 0.28; p = 0.017) 和 %∆ SOD (β = 0.24; p = 0.047) 呈正相关。白人显示 CSWA 与 %∆ SOD (β = -0.22; p = 0.042) 呈负相关，eGFR 与 %∆ GPx (β = 0.33; p = 0.001) 和 %∆ GR (β = 0.39; p) 呈正相关< 0.001)。在白人男性中，CSWA 与 SOD 活性降低的关联表明氧化应激相关的颈动脉重塑，而 eGFR 与谷胱甘肽系统的关联表明微血管恶化的延迟。
京公网安备 11010802027423号