A concise route for the preparation of two simple optically pure indolizidin-5-ones has been developed. The key chain elongation process was achieved using a triethylborane/catechol mediated hydroalkylation of Boc-protected 2-vinylpyrrolidines. By using complementary strategies, these two bicyclic lactams can be alkylated with complete control of the stereochemistry at C(5) and their conversion to a variety of indolizidine alkaloids such as coniceine, indolizidine 209D and 167B, 5-epi-indolizidine 249A and monomorine has been reported in the literature.

中文翻译：

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自由基介导的2-乙烯基吡咯烷衍生物的加氢烷基化：吲哚并立生物碱的多用途进入

已经开发了制备两种简单的光学纯的吲哚利兹-5-酮的简捷方法。使用Boc保护的2-乙烯基吡咯烷的三乙基硼烷/邻苯二酚介导的加氢烷基化作用实现了关键链的延长过程。通过使用互补策略，可以在完全控制C（5）的立体化学的情况下将这两个双环内酰胺烷基化，并将其转化为多种吲哚并立生物碱，例如康乃馨，吲哚并立定209D和167B，5-表位-吲哚并立定249A，单mor有文献报道。