Endothelial cells (ECs) line the quiescent vasculature but can form new blood vessels (a process termed angiogenesis) in disease. Strategies targeting angiogenic growth factors have been clinically developed for the treatment of malignant and ocular diseases. Studies over the past decade have documented that several pathways of central carbon metabolism are necessary for EC homeostasis and growth, and that strategies that stimulate or block EC metabolism can be used to promote or inhibit vessel growth, respectively. In this Review, we provide an updated overview of the growing understanding of central carbon metabolic pathways in ECs and the therapeutic opportunities for targeting EC metabolism.

内皮细胞（EC）位于静止的脉管系统中，但可以在疾病中形成新的血管（称为血管生成的过程）。在临床上已经开发出了针对血管生成生长因子的策略，用于治疗恶性和眼部疾病。过去十年的研究表明，中央碳代谢的几种途径对于EC的稳态和生长是必不可少的，并且刺激或阻断EC代谢的策略可分别用于促进或抑制血管的生长。在本综述中，我们提供了对EC中中央碳代谢途径的日益增长的了解以及针对EC代谢的治疗机会的最新概述。