A 32-year-old man suffered from Crohn’s disease of the terminal ileum and colon for 14 years, responding poorly to medical treatment. On endoscopy, several polyp-like lesions were seen in the bowel wall [Figure 1A]. He developed severe stenosis and underwent total colectomy. In the resected bowel, macroscopic features of Crohn’s disease were present [ulcers, inflammation, stricture]. In addition, there were at least 20 nodular lesions in the bowel wall measuring up to 2 cm in diameter, filled with mucin and covered by macroscopically normal mucosa [Figure 1B]. Microscopically, they consisted of cystically dilated glands in the submucosa and muscularis propria, without atypia [Figure 1C], suggesting the diagnosis of colitis cystica profunda [CCP].

中文翻译：

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克罗恩病中的弥漫性结肠炎囊肿深部：潜在的诊断误区。

一名32岁的男子患有回肠末端和结肠的克罗恩病14年，对药物的反应较差。在内窥镜检查中，在肠壁中发现了几个息肉样病变[图1A]。他发展为严重狭窄并接受了全结肠切除术。在切除的肠中，存在克罗恩氏病的宏观特征[溃疡，炎症，狭窄]。此外，肠壁上至少有20个结节性病变，直径达2 cm，充满黏液并被肉眼可见的正常黏膜覆盖[图1B]。在显微镜下，它们由粘膜下层和固有肌层中的囊性扩张腺体组成，无异型性状[图1C]，提示诊断为膀胱深部结肠炎[CCP]。