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Stay at home with the amyotrophic lateral sclerosis functional rating scale.
Journal of Neurology, Neurosurgery, and Psychiatry ( IF 8.7 ) Pub Date : 2019-09-26 , DOI: 10.1136/jnnp-2019-321707
Christopher J McDermott 1, 2
Affiliation  

In this issue, Bakker and colleagues report on the development and assessment of the performance of a self-administered version of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R).1 The ALSFRS, subsequently revised to ALSFRS-R is a functional outcome measure for ALS trials and has been shown to correlate with survival and muscle strength.2 As an outcome measure, it is not without its problems including multidimensionality, non-linearity, poor sensitivity to change in latter stages of disease and the absence of a cognitive function domain.3 4 Survival has traditionally been seen as the gold standard outcome measure; however, such trials are long and expensive. This has led to …

中文翻译:

用肌萎缩性侧索硬化功能评分表待在家里。

在本期中,Bakker及其同事报告了修订版的肌萎缩性侧索硬化症功能评分量表(ALSFRS-R)的自我管理版本的开发和性能评估。1ALSFRS(后来修订为ALSFRS-R是一种功能ALS试验的结局指标已显示与生存和肌肉力量相关。2作为结局指标,它并非没有问题,包括多维性,非线性,对疾病后期变化的敏感性差以及缺乏抗精神病药。认知功能领域。34传统上,生存率被视为黄金标准的结果指标。但是,这样的试验是漫长而昂贵的。这导致……
更新日期:2019-12-18
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