Aberrant lipid metabolism, central to atherosclerosis, is mechanistically influenced by insulin resistance and nonalcoholic fatty liver disease (NAFLD), which favors production and secretion of large very low-density lipoprotein (VLDL) particles from the liver(1). These large VLDL particles are slowly metabolized in the periphery, leading to formation of atherogenic small dense low-density lipoprotein (sdLDL) particles(2).

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回复信：HEP-18-1513.R3 - 小密度低密度脂蛋白胆固醇预测肝移植受者的心血管事件

异常脂质代谢是动脉粥样硬化的核心，受到胰岛素抵抗和非酒精性脂肪肝 (NAFLD) 的机械影响，NAFLD 有利于肝脏产生和分泌大的极低密度脂蛋白 (VLDL) 颗粒 (1)。这些大的 VLDL 颗粒在外周缓慢代谢，导致形成致动脉粥样硬化的小密度低密度脂蛋白 (sdLDL) 颗粒 (2)。