The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab (461 unique molecules, as of 5 August 2019) are downloadable as a single file with accompanying metadata.

中文翻译：

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Thera-SAbDab：治疗性结构抗体数据库。

治疗性结构抗体数据库（Thera-SAbDab；http://opig.stats.ox.ac.uk/webapps/therasabdab）追踪世界卫生组织 (WHO) 认可的所有抗体和纳米抗体相关疗法，并识别任何结构抗体数据库 (SAbDab) 中的相应结构具有近乎精确或精确的可变域序列匹配。Thera-SAbDab 与 SAbDab 同步每周更新，反映新的蛋白质数据库条目以及 WHO 发布的新序列数据的可用性。每个治疗摘要页面都列出了结构覆盖范围（带有指向相应 SAbDab 条目的链接）、显示任何接近匹配序列偏差的比对以及随附的元数据，例如预期目标和研究条件。Thera-SAbDab 可以通过治疗名称、元数据组合或可变域序列进行查询 - 返回查询指定区域内指定序列同一性内的所有治疗药物。Thera-SAbDab 中列出的所有疗法的序列（截至 2019 年 8 月 5 日，有 461 种独特分子）可作为单个文件与随附元数据下载。