Overweight and obesity, defined as ‘ abnormal or excessive fat accumulation that may impair health’ ,1 has nearly tripled since 1975. With ~1.9 billion and 650 million adults overweight and obese, respectively, these conditions have reached epidemic levels,1 with devastating health consequences.2 Traditionally, in clinical practice, diagnosis is made with the use of anthropometric measures (height and weight, waist and hip circumferences), while weight loss is the treatment goal for all interventions. Despite this, the scientific understanding of the pathophysiology of obesity has evolved, revealing ‘the many shades of adiposity’ (figure 1) that underlie this …

中文翻译：

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信息图表。肥胖的多种阴影

超重和肥胖（定义为“可能损害健康的异常或过度脂肪堆积”1）自 1975 年以来几乎增加了两倍。分别有约 19 亿和 6.5 亿成年人超重和肥胖，这些情况已达到流行水平，1 对健康造成破坏2 传统上，在临床实践中，诊断是通过使用人体测量指标（身高和体重、腰围和臀围）进行的，而体重减轻是所有干预措施的治疗目标。尽管如此，对肥胖病理生理学的科学理解已经发展，揭示了造成这种情况的“多种肥胖阴影”（图 1）……