Is liver fibrosis just liver fibrosis? Or do the subtype of collagen, its spatial localization in the liver, its cell of origin, and the time point at which it is synthesized also matter? It is important, since the various collagen subtypes hold different informative values regarding reparative processes in the liver, and as collagens have also emerged as important signaling molecules (1). Novel data have challenged our perception of liver fibrosis and collagens, which may have important implications regarding the development of new biomarkers and anti-fibrotic interventions. The traditional histological analysis of liver biopsies using histochemical collagen stains, such as the Masson's Trichrome stain or the Sirius Red stain, group all triple helical collagen structures into one gross bucket. Importantly, these stains ignore many other quantitatively minor but nonetheless functionally and structurally relevant collagen and non-collagen extracellular matrix (ECM) components.

中文翻译：

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在脂肪性肝炎引起的肝纤维化中，总量是否与胶原蛋白的定位和类型一样重要？

肝纤维化只是肝纤维化吗？或者胶原蛋白的亚型、它在肝脏中的空间定位、它的起源细胞以及它合成的时间点也很重要？重要的是，由于各种胶原亚型在肝脏修复过程中具有不同的信息价值，而且胶原蛋白也已成为重要的信号分子 (1)。新数据挑战了我们对肝纤维化和胶原蛋白的看法，这可能对开发新的生物标志物和抗纤维化干预措施具有重要意义。使用组织化学胶原染色（例如马森三色染色或天狼星红染色）对肝脏活检进行传统的组织学分析，将所有三螺旋胶原结构归为一个整体。重要的，