Reactivity of some 5-substituted tetrazoles with pentafluoropyridine under basic conditions in acetonitrile was investigated. The reaction of pentafluoropyridine with tetrazoles regioselectively occurs at the 4-position of pyridine ring by N2 in the tetrazole ring. Tetrazoles with substituents at the position 5 such as Ph, 4-NO₂C₆H₄, 4-CF₃CONHC₆H₄, 4-ClC₆H₄CH₂, EtOOCCH₂, and 5-tetrazolyl−CH₂ gave products containing unchanged tetrazole moiety. In contrast, tetrazole with substituents at the position 5 such as 3-(5-tetrazolyl)C₆H₄, 4-MeOC₆H₄, and 3-CF₃CONHC₆H₄, gave hydrazide products via degradation of tetrazole ring.

在碱性条件下，研究了一些5-取代的四唑与五氟吡啶在乙腈中的反应性。五氟吡啶与四唑的区域选择性地在吡啶环的4-位被四唑环中的N 2发生。用的取代基的四唑在位置5，如pH值，4-NO ₂ C ^ ₆ ħ ₄，4-CF ₃ CONHC ₆ H ^ ₄，4-CLC ₆ ħ ₄ CH ₂，EtOOCCH ₂，和5-四唑基-CH ₂，得到的产品含有未改变的四唑部分。相反，在位置5具有取代基的四唑，例如3-（5-四唑基）C ₆ H_4、4 -MeOC ₆ H ₄和3-CF ₃ CONHC ₆ H ₄通过四唑环的降解得到酰肼产物。