Hepatic stellate cells (HSCs), a key player in the progression of liver fibrosis, are activated by various inflammatory stimuli and converted to myofibroblast‐like cells with excessive collagen production. Despite many attempts to suppress activation of HSCs or inhibit collagen production in activated HSCs, their clinical applications have not been established yet. Recently, the deactivation of HSCs has been reported as a mechanism underlying the reversibility of experimental liver fibrosis. In the present study, we sought for deactivation factors of HSCs that induce regression of established liver fibrosis.

中文翻译：

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一种新的纤维化肝星状细胞失活因子诱导小鼠肝纤维化消退

肝星状细胞 (HSC) 是肝纤维化进程中的关键参与者，可被各种炎症刺激激活并转化为胶原蛋白生成过多的肌成纤维细胞样细胞。尽管有许多尝试抑制 HSC 的活化或抑制活化的 HSC 中胶原蛋白的产生，但它们的临床应用尚未建立。最近，已经报道了 HSC 的失活是实验性肝纤维化可逆性的一种机制。在本研究中，我们寻求诱导已建立的肝纤维化消退的 HSC 失活因子。