The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

中文翻译：

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PharmVar GeneFocus：CYP2D6。

药物遗传学变异协会（PharmVar）为高度多态的人CYP2D6基因位点提供了命名法。CYP2D6的遗传变异影响多种药物的代谢，因此会影响药物的功效和安全性。本GeneFocus提供了CYP2D6遗传变异的全面概述和摘要，并描述了药物基因组学知识库（PharmGKB）和临床药物遗传学实施联盟（CPIC）如何利用PharmVar提供的信息。