Crohn’s disease [CD] and ulcerative colitis [UC] are distinct forms of inflammatory bowel disease. Heterogeneity of HLA-DR⁺SIRPα ⁺ mononuclear phagocytes [MNPs], including macrophages [MΦ], monocyte-derived [Mono] cells, and dendritic cells [DCs], was reported in gut tissue but not yet investigated in mesenteric lymph nodes [MLNs] of IBD patients. We here compared the phenotype, function, and molecular profile of HLA-DR⁺SIRPα ⁺ MNPs in CD and UC MLNs.

中文翻译：

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肠系膜淋巴结中单核吞噬细胞的转录组分析和高维表型图谱揭示了溃疡性结肠炎和克罗恩病之间的差异


克罗恩病 [CD] 和溃疡性结肠炎 [UC] 是两种不同形式的炎症性肠病。据报道，肠道组织中存在 HLA-DR ⁺ SIRPα ⁺单核吞噬细胞 [MNP] 的异质性，包括巨噬细胞 [MΦ]、单核细胞来源的 [Mono] 细胞和树突状细胞 [DC]，但尚未在肠系膜淋巴结 [MLN] 中进行研究] IBD 患者。我们在此比较了 CD 和 UC MLN 中 HLA-DR ⁺ SIRPα ⁺ MNP 的表型、功能和分子概况。