The conserved Hippo pathway regulates organ size, tissue homeostasis, and tumorigenesis. Interferon regulatory factor 2 binding protein 2 (IRF2BP2) was originally identified as a transcriptional corepressor. However, the association between IRF2BP2 and the Hippo pathway remains largely unknown. In addition, the biological function and regulation mechanism of IRF2BP2 in liver cancer are poorly understood.

中文翻译：

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新型抑癌基因 IRF2BP2 通过反馈回路调节肝癌中的 Hippo 通路

保守的 Hippo 通路调节器官大小、组织稳态和肿瘤发生。干扰素调节因子 2 结合蛋白 2 (IRF2BP2) 最初被确定为转录辅助抑制因子。然而，IRF2BP2 和 Hippo 通路之间的关联在很大程度上仍然未知。此外，IRF2BP2在肝癌中的生物学功能和调控机制也知之甚少。