Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and 2015 in Latin America. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicable guideline for the diagnosis and management of GBS. The guideline is based on current literature and expert consensus, and has a ten-step structure to facilitate its use in clinical practice. We first provide an introduction to the diagnostic criteria, clinical variants and differential diagnoses of GBS. The ten steps then cover early recognition and diagnosis of GBS, admission to the intensive care unit, treatment indication and selection, monitoring and treatment of disease progression, prediction of clinical course and outcome, and management of complications and sequelae.

中文翻译：

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格林-巴利综合征的诊断和管理分十步。

格林-巴利综合征 (GBS) 是一种罕见但可能致命的免疫介导的周围神经和神经根疾病，通常由感染引发。因此，GBS 的发病率在传染病爆发期间会增加，正如 2013 年法属波利尼西亚和 2015 年拉丁美洲寨卡病毒流行期间所见。GBS 的诊断和管理可能很复杂，因为它的临床表现和病程是异质的，并且目前没有国际临床指南可用。为了支持临床医生，尤其是在疫情爆发的情况下，我们制定了全球适用的 GBS 诊断和管理指南。该指南基于当前的文献和专家共识，具有十个步骤的结构，以促进其在临床实践中的应用。我们首先介绍GBS的诊断标准、临床变异和鉴别诊断。这十个步骤包括早期识别和诊断 GBS、入住重症监护室、治疗适应症和选择、监测和治疗疾病进展、预测临床过程和结果以及管理并发症和后遗症。