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Enhanced teeth whitening by nanofluidic transport of hydrogen peroxide into enamel with electrokinetic flows.
Dental Materials ( IF 4.6 ) Pub Date : 2019-09-20 , DOI: 10.1016/j.dental.2019.08.118
Chenhui Peng 1 , Sohyun Park 2 , Frederico Barbosa de Sousa 3 , HiongYap Gan 4 , Sang J Lee 2 , Wei Wang 5 , Stacey Lavender 5 , Shira Pilch 5 , Jongyoon Han 6
Affiliation  

Tooth whitening, a routine procedure in dentistry, is one of the examples of medical procedures that are limited by the challenge of delivering molecules into various types of nanoporous tissues. Current bleaching methods rely on simple diffusion of peroxides into enamel nano channels, therefore requires sufficient contact time with peroxides. In-office treatments often involve enamel etching or light activation which often results in patient sensitivity and potential soft tissue damage. OBJECTIVE To demonstrate a robust method to transport hydrogen peroxide to greater depths into enamel nanopores through nanofluidic flows driven by electrokinetics, with the intention to increase efficacy while reducing treatment time. METHODS Freshly extracted human teeth were subjected to electrokinetic flow treatment with hydrogen peroxide under different electric fields with varying operation times. Pre- and post-operative shade matching was done using a photospectrometer. RESULTS It is demonstrated that the operation time for the same concentration of hydrogen peroxide can be shortened by 10 times. The proposed method showed significant improvements in whitening effects over control groups and thus offers promising clinically-viable chairside applications with efficacy. SIGNIFICANCE The demonstrated nanofluidic transport of hydrogen peroxide into enamel has a potential to be applied for enhancing tooth whitening, compared to simple diffusion, without heating the hard dental tissues.

中文翻译:

通过电动势将过氧化氢纳米流体输送到牙釉质中增强牙齿美白。

牙齿增白是牙科中的常规程序,是医疗程序的示例之一,其受到将分子递送到各种类型的纳米多孔组织中的挑战的限制。当前的漂白方法依赖于过氧化物简单地扩散到搪瓷纳米通道中,因此需要与过氧化物充分的接触时间。办公室内的治疗通常涉及搪瓷蚀刻或光激活,这通常会导致患者敏感并可能导致软组织损伤。目的展示一种可靠的方法,可通过电动学驱动的纳米流体流将过氧化氢更深地输送到牙釉质纳米孔中,目的是在减少治疗时间的同时提高功效。方法对刚拔出的人牙齿在不同的电场,不同的操作时间下用过氧化氢进行电动流动处理。术前和术后的阴影匹配是使用分光光度计完成的。结果表明,相同浓度的过氧化氢的操作时间可以缩短10倍。所提出的方法与对照组相比,在增白效果上显示出显着的改善,因此具有有效的临床可行的椅边应用。意义与简单的扩散相比,已证明的纳米流体将过氧化氢纳米流体输送到牙釉质中有可能被用于增强牙齿的美白性,而无需加热坚硬的牙齿组织。术前和术后的阴影匹配是使用分光光度计完成的。结果表明,相同浓度的过氧化氢的操作时间可以缩短10倍。所提出的方法与对照组相比,在增白效果上显示出显着的改善,因此具有有效的临床可行的椅边应用。意义与简单的扩散相比,已证明的纳米流体将过氧化氢纳米流体输送到牙釉质中有可能被用于增强牙齿的美白性,而无需加热坚硬的牙齿组织。术前和术后的阴影匹配是使用分光光度计完成的。结果表明,相同浓度的过氧化氢的操作时间可以缩短10倍。所提出的方法与对照组相比,在增白效果上显示出显着的改善,因此具有有效的临床可行的椅边应用。意义与简单的扩散相比,已证明的纳米流体将过氧化氢纳米流体输送到牙釉质中有潜力用于增强牙齿的美白性,而无需加热坚硬的牙齿组织。所提出的方法与对照组相比,在增白效果方面显示出显着的改善,因此可提供具有前景的临床可行的椅边应用。意义与简单的扩散相比,已证明的纳米流体将过氧化氢纳米流体输送到牙釉质中有可能被用于增强牙齿的美白性,而无需加热坚硬的牙齿组织。所提出的方法与对照组相比,在增白效果上显示出显着的改善,因此具有有效的临床可行的椅边应用。意义与简单的扩散相比,已证明的纳米流体将过氧化氢纳米流体输送到牙釉质中有可能被用于增强牙齿的美白性,而无需加热坚硬的牙齿组织。
更新日期:2019-09-21
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