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Metabolomic profiles associated with exposure to per- and polyfluoroalkyl substances (PFASs) in aquatic environments.
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2019-09-19 , DOI: 10.1039/c9em00394k
Matthew D Taylor 1 , Jennifer Bräunig 2 , Jochen F Mueller 2 , Marcus Crompton 3 , R Hugh Dunstan 3 , Sandra Nilsson 2
Affiliation  

Per- and polyfluoroalkyl substances (PFASs) are frequently detected in aquatic environments. Longer chained perfluoroalkyl acids (PFAAs), in particular, have been found to bioaccumulate in a broad range of aquatic biota. PFAAs have a physiochemical similarity to naturally occurring fatty acids and could potentially disrupt metabolic processes, however, there has been limited study in this area, especially in aquatic species. In this study, the associations between PFAAs and metabolite profiles were investigated in crustaceans. Eastern School Prawn (Metapenaeus macleayi) were obtained from three different locations (n = 15 per location) with similar environmental conditions but different levels of PFAA contamination. The concentrations of PFAAs, fatty acids and amino acids were analysed and differences in PFAA and metabolite profiles were evaluated. Different PFAA profiles were mirrored by significant differences in the composition of both fatty acid and amino acid profiles, indicating a potential association between PFAA concentration and the composition of metabolites in prawns. These results highlight a need for further research investigating the impacts of PFAA exposure, with the current study providing a foundation for further investigation of the relationship between PFAA bioaccumulation and organism metabolism.

中文翻译:

与水生环境中全氟烷基物质和多氟烷基物质(PFAS)的暴露相关的代谢组学概况。

在水生环境中经常检测到全氟烷基物质和多氟烷基物质(PFAS)。特别是,长链全氟烷基酸(PFAA)已发现在广泛的水生生物区系中具有生物蓄积性。PFAA与天然存在的脂肪酸在理化上有相似性,并可能破坏代谢过程,但是,在这一领域,尤其是在水生物种中的研究还很有限。在这项研究中,在甲壳类动物中研究了PFAAs与代谢物谱之间的关联。东方虾(Metapenaeus macleayi)从三个不同的地方(n= 15个位置),环境条件相似,但PFAA污染水平不同。分析了PFAA,脂肪酸和氨基酸的浓度,并评估了PFAA和代谢物谱的差异。脂肪酸和氨基酸谱组成的显着差异反映了不同的PFAA谱,表明对虾的PFAA浓度与代谢物组成之间存在潜在的联系。这些结果凸显了需要进行进一步研究以研究PFAA暴露的影响,而当前的研究为进一步研究PFAA生物蓄积与生物体代谢之间的关系提供了基础。
更新日期:2019-09-19
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