Astrocytes in chronic pain and itch.,Nature Reviews Neuroscience

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Astrocytes in chronic pain and itch.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-09-19 , DOI: 10.1038/s41583-019-0218-1
Ru-Rong Ji _{1,

2} , Christopher R Donnelly ₁ , Maiken Nedergaard _{3,

4}

Affiliation

Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders, including chronic pain, may result from astrocyte 'gliopathy'. Indeed, in recent years there has been substantial progress in our understanding of how astrocytes can regulate nociceptive synaptic transmission via neuronal-glial and glial-glial cell interactions, as well as the involvement of spinal and supraspinal astrocytes in the modulation of pain signalling and the maintenance of neuropathic pain. A role of astrocytes in the pathogenesis of chronic itch is also emerging. These developments suggest that targeting the specific pathways that are responsible for astrogliopathy may represent a novel approach to develop therapies for chronic pain and chronic itch.

中文翻译：

星形胶质细胞在慢性疼痛和瘙痒中。

星形胶质细胞对于维持中枢神经系统的稳态至关重要。越来越多的证据表明，星形胶质细胞“神经胶质病变”可能导致许多神经系统疾病和神经精神疾病，包括慢性疼痛。确实，近年来，我们对星形胶质细胞如何通过神经元-神经胶质细胞和神经胶质细胞-胶质细胞相互作用调节脊髓伤害性突触传递以及脊髓和脊髓上星形胶质细胞参与疼痛信号传导和调节的理解有了实质性的进展。维持神经性疼痛。星形胶质细胞在慢性瘙痒的发病机理中的作用也正在出现。这些发展表明，针对负责星形胶质细胞变性的特定途径的靶向可能代表了开发针对慢性疼痛和慢性瘙痒的疗法的新颖方法。

更新日期：2019-09-20

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