Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease linked to symptoms including fatigue and altered mood/cognition, indicating that chronic liver inflammation associated with PBC can impact brain function. We employed near‐infrared spectroscopy (NIRS), a noninvasive neuroimaging technique, to determine whether patients with PBC exhibit reduced cerebral oxygen saturation (StO2) and altered patterns of microvascular cerebral blood perfusion and whether these alterations were associated with clinical phenotype. This observational case–control study was conducted at a tertiary hospital clinic (University of Calgary Liver Unit).

中文翻译：

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近红外光谱揭示原发性胆汁性胆管炎脑缺氧和脑血管失调

原发性胆汁性胆管炎 (PBC) 是一种自身免疫性胆汁淤积性肝病，与疲劳和情绪/认知改变等症状有关，表明与 PBC 相关的慢性肝脏炎症会影响大脑功能。我们采用近红外光谱 (NIRS)，一种无创神经成像技术，来确定 PBC 患者是否表现出脑氧饱和度 (StO2) 降低和微血管脑血灌注模式改变，以及这些改变是否与临床表型相关。这项观察性病例对照研究是在一家三级医院诊所（卡尔加里大学肝脏科）进行的。