Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1.,The Journal of Antibiotics

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Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-09-18 , DOI: 10.1038/s41429-019-0234-4
Yudai Kuroda ₁ , Haruka Yamagata ₂ , Michiko Nemoto ₂ , Kenji Inagaki ₂ , Takashi Tamura ₂ , Ken Maeda ₁

Affiliation

Feline herpesvirus type 1 (FHV-1) causes a potentially fatal disease in cats. Through the use of virus inhibition and cytotoxicity assays, sinefungin, a nucleoside antibiotic, was assessed for its potential to inhibit the growth of FHV-1. Sinefungin inhibited in vitro growth of FHV-1 most significantly over other animal viruses, such as feline infectious peritonitis virus, equine herpesvirus, pseudorabies virus and feline calicivirus. Our results revealed that sinefungin specifically suppressed the replication of FHV-1 after its adsorption to the host feline kidney cells in a dose-dependent manner without obvious cytotoxicity to the host cells. This antibiotic can potentially offer a highly effective treatment for animals infected with FHV-1, providing alternative medication to currently available antiviral therapies.

中文翻译：

sinefungin对猫疱疹病毒1型体外生长的抗病毒作用。

猫疱疹病毒 1 型 (FHV-1) 在猫身上引起潜在的致命疾病。通过使用病毒抑制和细胞毒性测定，评估了核苷类抗生素 sinefungin 抑制 FHV-1 生长的潜力。与其他动物病毒如猫传染性腹膜炎病毒、马疱疹病毒、伪狂犬病病毒和猫杯状病毒相比，Sinefungin 最显着地抑制 FHV-1 的体外生长。我们的研究结果表明，sinefungin 以剂量依赖性方式特异性抑制 FHV-1 吸附到宿主猫肾细胞后的复制，而对宿主细胞没有明显的细胞毒性。这种抗生素可能为感染 FHV-1 的动物提供高效治疗，为目前可用的抗病毒疗法提供替代药物。

更新日期：2020-01-16

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