BACKGROUND AND AIM Major and trace elements play an important role in human body, and it has been reported that ionomic distribution differ greatly in tumor patients. The aim of the present study was to investigate the effects of cisplatin-based neoadjuvant chemoradiotherapy on the ionomic profile in human plasma as a potential biomarker for the therapeutic effects of cervical cancer. METHOD Thirty-seven patients with cervical cancer receiving neoadjuvant chemoradiotherapy were included in this study, pretherapy and post-treatment blood samples were collected and concentrations of 24 ions were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). RESULTS The results showed that after cisplatin chemotherapy and radiotherapy, patients' plasma Pt level significantly increased, Na, Mg, P, K, Ca, Se, Cu, Zn, Se, Sr, Ba levels significantly decreased (P < 0.01), and Al, Cu ions were significantly correlated with the treatment effect (P < 0.05). In addition, the pattern of elemental correlations changed dramatically after the neoadjuvant chemoradiotherapy. CONCLUSION The results indicated that the plasma ionomic profile may serve as a quick and convenient tool to reflect the therapeutic effect of cisplatin-based chemoradiotherapy in cervical cancer patients, and supplement of certain essential elements may be of great importance for the maintenance of ion homeostasis in human body and for the reduction of adverse effect of chemotherapy and radiotherapy.

中文翻译：

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接受新辅助放化疗的子宫颈癌患者血浆中的基因组学特征具有诊断潜力。

背景与目的主要和微量元素在人体中起着重要的作用，据报道在肿瘤患者中碘的分布存在很大差异。本研究的目的是研究基于顺铂的新辅助放化疗对人血浆中的药物学特征的影响，作为宫颈癌治疗效果的潜在生物标志物。方法纳入37例接受新辅助放化疗的宫颈癌患者，收集治疗前和治疗后的血样，并通过电感耦合等离子体质谱法（ICP-MS）分析24种离子的浓度。结果结果表明，顺铂化疗和放疗后，患者血浆Pt水平显着升高，Na，Mg，P，K，Ca，Se，Cu，Zn，Se，Sr，钡水平显着降低（P <0.01），铝，铜离子与治疗效果显着相关（P <0.05）。此外，新辅助放化疗后，元素相关的模式发生了巨大变化。结论结果表明，血浆碘仿谱可作为反映宫颈癌患者基于顺铂的放化疗的疗效的便捷工具，补充某些必需元素对于维持体内离子稳态是非常重要的。并用于减少人体对化学疗法和放射疗法的不良反应。新辅助放化疗后，元素相关性的模式发生了巨大变化。结论结果表明，血浆碘仿谱可作为反映宫颈癌患者基于顺铂的放化疗的疗效的便捷工具，补充某些必需元素对于维持体内离子稳态是非常重要的。并用于减少人体对化学疗法和放射疗法的不良反应。新辅助放化疗后，元素相关性的模式发生了巨大变化。结论结果表明，血浆碘仿谱可作为一种快速便捷的工具，以反映基于顺铂的放化疗在宫颈癌患者中的治疗效果，补充某些必需元素对于维持体内离子稳态是非常重要的。并用于减少人体对化学疗法和放射疗法的不良反应。