Research on RNA-associated interactions has exploded in recent years, and increasing numbers of studies are not limited to RNA-RNA and RNA-protein interactions but also include RNA-DNA/compound interactions. To facilitate the development of the interactome and promote understanding of the biological functions and molecular mechanisms of RNA, we updated RAID v2.0 to RNAInter (RNA Interactome Database), a repository for RNA-associated interactions that is freely accessible at http://www.rna-society.org/rnainter/ or http://www.rna-society.org/raid/. Compared to RAID v2.0, new features in RNAInter include (i) 8-fold more interaction data and 94 additional species; (ii) more definite annotations organized, including RNA editing/localization/modification/structure and homology interaction; (iii) advanced functions including fuzzy/batch search, interaction network and RNA dynamic expression and (iv) four embedded RNA interactome tools: RIscoper, IntaRNA, PRIdictor and DeepBind. Consequently, RNAInter contains >41 million RNA-associated interaction entries, involving more than 450 thousand unique molecules, including RNA, protein, DNA and compound. Overall, RNAInter provides a comprehensive RNA interactome resource for researchers and paves the way to investigate the regulatory landscape of cellular RNAs.

中文翻译：

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2020年的RNAInter：具有更大覆盖范围和注释的RNA交互基因组存储库。

近年来，与RNA相关的相互作用的研究激增，并且越来越多的研究不仅限于RNA-RNA和RNA-蛋白质的相互作用，还包括RNA-DNA /化合物的相互作用。为了促进相互作用组的发展并增进对RNA的生物学功能和分子机制的了解，我们将RAID v2.0更新为RNAInter（RNA相互作用组数据库），RNAInter相互作用组是一个与RNA相关的相互作用的存储库，可从以下网址免费访问： www.rna-society.org/rnainter/或http://www.rna-society.org/raid/。与RAID v2.0相比，RNAInter的新功能包括：（i）交互数据增加了8倍，另外增加了94种。（ii）组织更明确的注释，包括RNA编辑/定位/修饰/结构和同源性相互作用；（iii）先进的功能，包括模糊/批量搜索，相互作用网络和RNA动态表达，以及（iv）四个嵌入式RNA相互作用组工具：RIscoper，IntaRNA，PRIdictor和DeepBind。因此，RNAInter包含超过4,100万与RNA相关的相互作用条目，涉及超过45万个独特分子，包括RNA，蛋白质，DNA和化合物。总体而言，RNAInter为研究人员提供了全面的RNA相互作用组资源，并为研究细胞RNA的调控前景铺平了道路。