A framework for examining how diet impacts tumour metabolism.,Nature Reviews Cancer

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A framework for examining how diet impacts tumour metabolism.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2019-09-17 , DOI: 10.1038/s41568-019-0198-5
Evan C Lien _{1,

2} , Matthew G Vander Heiden _{1,

2,

3}

Affiliation

The way cancer cells utilize nutrients to support their growth and proliferation is determined by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the environment. These interactions can define therapeutic vulnerabilities and impact the effectiveness of cancer therapy. Diet-mediated changes in whole-body metabolism and systemic nutrient availability can affect the environment that cancer cells are exposed to within tumours, and a better understanding of how diet modulates nutrient availability and utilization by cancer cells is needed. How diet impacts cancer outcomes is also of great interest to patients, yet clear evidence for how diet interacts with therapy and impacts tumour growth is lacking. Here we propose an experimental framework to probe the connections between diet and cancer metabolism. We examine how dietary factors may affect tumour growth by altering the access to and utilization of nutrients by cancer cells. Our growing understanding of how certain cancer types respond to various diets, how diet impacts cancer cell metabolism to mediate these responses and whether dietary interventions may constitute new therapeutic opportunities will begin to provide guidance on how best to use diet and nutrition to manage cancer in patients.

中文翻译：

研究饮食如何影响肿瘤代谢的框架。

癌细胞利用营养物质来支持其生长和增殖的方式取决于癌细胞内在和癌细胞外在因素，包括与环境的相互作用。这些相互作用可以定义治疗漏洞并影响癌症治疗的有效性。饮食介导的全身代谢和全身营养供应变化会影响癌细胞在肿瘤内暴露的环境，因此需要更好地了解饮食如何调节癌细胞的营养供应和利用。饮食如何影响癌症结果也引起了患者的极大兴趣，但缺乏关于饮食如何与治疗相互作用并影响肿瘤生长的明确证据。在这里，我们提出了一个实验框架来探索饮食和癌症代谢之间的联系。我们研究了饮食因素如何通过改变癌细胞对营养物质的获取和利用来影响肿瘤的生长。我们对某些癌症类型如何对各种饮食作出反应、饮食如何影响癌细胞代谢以介导这些反应以及饮食干预是否可能构成新的治疗机会的认识不断加深，这将开始为如何最好地使用饮食和营养来管理患者的癌症提供指导.

更新日期：2019-09-18

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